Our front cover features a spleen section from mice with B cells lacking the RNA-binding proteins PTBP1 and PTBP3. T cells are stained with an anti-CD3 antibody (blue) and B cells are stained with anti-IgM (magenta) and anti-IgD (yellow) antibodies. B cells lacking PTBP1 and PTBP3 have a severe defect in B cell development and maintenance. The image shows a very small B cell area surrounding the T cell zone. The image is taken from Monzón-Casanova et al. (pp. 2266–2273), where the authors show the indispensable roles of PTBP1 and PTBP3 in regulating post-transcriptional gene expression for the optimal development of B cells and the maintenance of mature B cells.

中文翻译：

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封面故事：欧元。J.免疫学。9'21

我们的封面展示了来自 B 细胞缺乏 RNA 结合蛋白 PTBP1 和 PTBP3 的小鼠脾脏切片。T 细胞用抗 CD3 抗体（蓝色）染色，B 细胞用抗 IgM（品红色）和抗 IgD（黄色）抗体染色。缺乏 PTBP1 和 PTBP3 的 B 细胞在 B 细胞发育和维持方面存在严重缺陷。图像显示了 T 细胞区周围的一个非常小的 B 细胞区域。该图像取自 Monzón-Casanova 等人。(pp. 2266–2273)，作者展示了 PTBP1 和 PTBP3 在调节转录后基因表达以优化 B 细胞发育和维持成熟 B 细胞中不可或缺的作用。