Dear Readers,

Team spirit is an essential quality required for success in any scientific discipline, and our team of Executive Committee (ExCo) members and in-house editors at EJI were thankful for a positive esprit de corps more than ever during the past year. Beyond working tirelessly to ensure we maintain the quality of published articles [1], we teamed up and gathered globally renowned experts in various fields of immunology with one aim: to honor EJI's 50^th Anniversary and join forces to prepare our 50^th Anniversary special collection [2]. As already mentioned in our previous editorial, the 50^th Anniversary review series features the most impactful topics in both basic and clinical immunology. Just at the time when we were finalizing the publication of the first reviews, we were extremely saddened to hear that our ExCo member Anca Catrina had passed away after a long-term struggle with severe illness [3]. We express our sincere condolences to her family and colleagues and our gratitude to Anca for all of her contributions to EJI. She will be greatly missed in our team. We also owe big thanks to ExCo members Maria Yazdanbakhsh and Wenjun Ouyang, who have given an important signature to the 50^th Anniversary series. Finally, we are indebted to the series Authors for their enthusiasm to join us for this journey. We are proud of our joint efforts reflected in the series content and we invite you to explore the published 50^th Anniversary Review Collection. You will discover a variety of topics, regardless of your field of research. The readers may also find answers to the questions they have been looking for or even get inspired to start a new line of research!

While the year 2020 is behind us, the ongoing pandemic continues to pose challenges for our global research community, especially those of us with small children. COVID-19 pandemics and lockdowns have negatively impacted primarily female scientists [4] and we could clearly witness this while preparing the 50^th Anniversary Collection. Although a number of female authors and key opinion leaders contributed to the current series, several lead female immunologists, despite initial enthusiasm to contribute, were finally not able to, since their regular daily roles as lab heads have suddenly switched to full time child-care and home schooling. We are nonetheless grateful for discussing review ideas with these researchers and fully understand the challenges the current times present.

Despite the COVID-19 pandemic, the international community of immunologists has been incredibly creative and collaborative. These trying times have shown us the importance of national and cross-national collaboration for publishing top articles in highly evolving field of coronavirus research [5-8]. We are very pleased with the COVID-19 articles published in EJI, and are excited to see that EJI's COVID-19 content continues to grow and has already received much attention; judging by the our top downloaded articles every month. We want to thank our authors and referees for working with us to rapidly disseminate COVID-19 research!

The current COVID-19 pandemic is not the only EJI content receiving attention. A seminal study published in EJI in 1993 [9] that set the stage for development of mRNA COVID-19 vaccination platforms, is as of recent in the limelight judging by its high Altmetric score. This revival is truly no wonder – the study by Martinon et al. indeed is one of the pioneering studies that suggested the high potential of liposome-encapsulated mRNA technology for vaccination by demonstrating the capacity of mRNA- containing liposomes to elicit CTL responses in vivo. Almost 30 years after this discovery the initial assumption of Meulien and collegues can't be more true! In retrospect, the very words of authors ‘’The interest of this novel approach lies in the ease of preparing mRNA-containing liposomes in comparison with the time-consuming task of identifying CTL epitopes or the isolation of enough pure viral protein’’ were a vision of future and have together with the work of other researchers in the field announced a revolution in the field of vaccine research that we continue to witness.

Another big reward to our team came with this year's impact factor (IF) announcement. We are more than happy to see that 2020 IF is 5.532 and has shown a 26% increase compared to the previous! We want to thank our dedicated authors, referees, Editorial Board members and our Executive committee for their hard work and contribution to this incredible achievement and we would also like to thank our global community of readers for their continued support. We will remain committed to publish significant studies that advance the field and not only those that are perceived as trendy or popular research. EJI will continue to serve the needs of our authors and readers around the globe and cover high-quality basic, clinical, and translational research.

Finally, we would like to entice you with what is coming next and announce that we have teamed-up with our global community of authors and are currently preparing the third edition of the Flow cytometry guidelines. The first and the second editions are still our most read articles [10, 11] and continue to prove that Guidelines are a valuable resource for many immunologists.

And before we close and ask you for your precious feedback, we would like to announce that you can follow us on our recently launched Twitter account and use this venue to hear about our recently published articles and developments in the Journal!

亲爱的读者，

团队精神是在任何科学学科取得成功所需的基本素质，我们的执行委员会 (ExCo) 成员和 EJI 的内部编辑团队在过去一年中比以往任何时候都更加感谢团队精神。除了不知疲倦地工作，以确保我们维持发表的文章[质量1 ]，我们联手，并与一个目标在全球范围聚集知名专家在免疫学的各个领域：兑现EJI的50^个周年联手准备了50^个周年纪念专集[ 2 ]。正如我们在之前的编辑已经提到，50^日周年回顾系列以基础和临床免疫学中最具影响力的主题为特色。就在我们完成第一批评论的出版时，我们非常难过地听到我们的执行委员会成员 Anca Catrina 在长期与严重疾病作斗争后去世 [ 3 ]。我们向她的家人和同事表示诚挚的哀悼，并感谢 Anca 为 EJI 所做的所有贡献。我们团队会非常想念她。我们也非常感谢执行委员会成员 Maria Yazdanbakhsh 和 Wenjun Ouyang，他们为第 50^届会议作出了重要签名。周年系列。最后，我们感谢系列作者的热情加入我们的旅程。我们对我们反映的一系列内容共同努力感到自豪，我们邀请您来探索发布的50^个周年回顾系列。无论您的研究领域如何，您都会发现各种主题。读者还可以找到他们一直在寻找的问题的答案，甚至可以得到启发，开始新的研究！

虽然 2020 年已经过去，但持续的大流行继续给我们的全球研究界带来挑战，尤其是我们这些有小孩的人。COVID-19流行病和lockdowns造成了负面影响主要是女性科学家[ 4 ]，我们可以清楚地看到这一点的同时准备50^个周年纪念收藏。尽管一些女性作者和主要意见领袖为当前系列做出了贡献，但几位主要的女性免疫学家尽管最初热衷于贡献，但最终无法做出贡献，因为她们作为实验室负责人的日常角色突然转变为全职儿童保育和家庭教育。尽管如此，我们还是很感谢与这些研究人员讨论评论想法，并充分了解当前面临的挑战。

尽管发生了 COVID-19 大流行，但国际免疫学家社区的创造力和协作能力令人难以置信。这些艰难的时期向我们展示了国家和跨国合作对于在高度发展的冠状病毒研究领域发表顶级文章的重要性 [ 5-8 ]。我们对 EJI 发表的 COVID-19 文章感到非常高兴，也很高兴看到 EJI 的 COVID-19 内容持续增长并已受到广泛关注；从我们每月下载次数最多的文章来看。我们要感谢我们的作者和审稿人与我们合作快速传播 COVID-19 研究！

当前的 COVID-19 大流行并不是唯一受到关注的 EJI 内容。1993 年发表在 EJI 上的一项开创性研究 [ 9] 为 mRNA COVID-19 疫苗接种平台的开发奠定了基础，从其高 Altmetric 得分来看，它最近成为人们关注的焦点。这种复兴确实不足为奇——Martinon 等人的研究。确实是开创性研究之一，通过证明含有 mRNA 的脂质体在体内引发 CTL 反应的能力，表明脂质体包裹的 mRNA 技术在疫苗接种方面具有巨大潜力。在这一发现将近 30 年后，Meulien 和同事的最初假设再正确不过了！回想起来，

对我们团队的另一个重大奖励是今年的影响因子 (IF) 公告。我们非常高兴地看到 2020 年 IF 为 5.532，与之前相比增长了 26%！我们要感谢我们敬业的作者、审稿人、编辑委员会成员和我们的执行委员会为这一令人难以置信的成就所做的辛勤工作和贡献，我们还要感谢我们的全球读者社区的持续支持。我们将继续致力于发表推动该领域发展的重要研究，而不仅仅是那些被视为流行或流行的研究。EJI 将继续满足全球作者和读者的需求，涵盖高质量的基础、临床和转化研究。

最后，我们想用接下来的内容吸引您，并宣布我们已与全球作者社区合作，目前正在准备第三版流式细胞术指南。第一版和第二版仍然是我们阅读量最大的文章 [ 10, 11 ]，并继续证明指南是许多免疫学家的宝贵资源。

在我们关闭并请求您提供宝贵的反馈之前，我们想宣布您可以在我们最近推出的 Twitter 帐户上关注我们，并使用这个场所来了解我们最近在期刊上发表的文章和进展！