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Drug delivery strategies for management of women’s health issues in the upper genital tract
Advanced Drug Delivery Reviews ( IF 16.1 ) Pub Date : 2021-09-01 , DOI: 10.1016/j.addr.2021.113955
Sravan Kumar Patel 1 , Guru Raghavendra Valicherla 1 , Amanda Catherine Micklo 1 , Lisa Cencia Rohan 2
Affiliation  

The female upper genital tract (UGT) hosts important reproductive organs including the cervix, uterus, fallopian tubes, and ovaries. Several pathologies affect these organ systems such as infections, reproductive issues, structural abnormalities, cancer, and inflammatory diseases that could have significant impact on women’s overall health. Effective disease management is constrained by the multifaceted nature of the UGT, complex anatomy and a dynamic physiological environment. Development of drug delivery strategies that can overcome mucosal and safety barriers are needed for effective disease management. This review introduces the anatomy, physiology, and mucosal properties of the UGT and describes drug delivery barriers, advances in drug delivery technologies, and opportunities available for new technologies that target the UGT.



中文翻译:

治疗上生殖道女性健康问题的给药策略

女性上生殖道 (UGT) 拥有重要的生殖器官,包括子宫颈、子宫、输卵管和卵巢。一些疾病会影响这些器官系统,例如感染、生殖问题、结构异常、癌症和炎症性疾病,这些疾病可能会对女性的整体健康产生重大影响。有效的疾病管理受到 UGT 的多面性、复杂的解剖结构和动态生理环境的限制。有效的疾病管理需要开发能够克服粘膜和安全障碍的药物递送策略。这篇综述介绍了 UGT 的解剖学、生理学和粘膜特性,并描述了药物输送障碍、药物输送技术的进步以及针对 UGT 的新技术的可用机会。

更新日期:2021-09-10
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