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Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
Journal of Natural Products ( IF 5.1 ) Pub Date : 2021-09-01 , DOI: 10.1021/acs.jnatprod.1c00365
Marco Masi 1 , Roberta Di Lecce 1 , Giulia Marsico 2 , Benedetto Teodoro Linaldeddu 3 , Lucia Maddau 4 , Stefano Superchi 2 , Antonio Evidente 1
Affiliation  

Two new bioactive trisubstituted furanones, named pinofuranoxins A and B (1 and 2), were isolated from Diplodia sapinea, a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and computational analyses of electronic circular dichroism spectra. They induced necrotic lesions on Hedera helix L., Phaseolus vulgaris L., and Quercus ilex L. Compound 1 completely inhibited the growth of Athelia rolfsii and Phytophthora cambivora, while 2 showed antioomycetes activity against P. cambivora. In the Artemia salina assay both toxins showed activity inducing larval mortality.

中文翻译:

Pinofuranoxins A 和 B,由入侵病原体 Diplodia sapinea 产生的生物活性三取代呋喃酮

Diplodia sapinea中分离出两种新的具有生物活性的三取代呋喃酮,名为 pinofuranoxins A 和 B(12),这是一种引起严重疾病的全球针叶树病原体。Pinofuranoxins A 和 B 的特征主要是通过 NMR 和 HRESIMS 光谱,并且它们的相对和绝对构型通过 NOESY 实验和电子圆二色光谱的计算分析来确定。他们在Hedera helix L.、Phaseolus vulgaris L. 和Quercus ilex L.上诱导坏死病变。化合物1完全抑制了Athelia rolfsiiPhytophthora cambivora的生长,而2P. cambivora显示出抗卵菌活性。在卤虫试验中,两种毒素均显示出诱导幼虫死亡的活性。
更新日期:2021-09-24
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