Rosacea is a common chronic skin disease affecting mostly people aged 40 and above, with currently no cure. When it affects the eyelids and periocular skin, it leads to dry eye and potentially corneal damage. Research performed over the last decade shed light into the potential mechanisms leading to skin hypersensitivity and provided promising avenues for development of novel, rational therapeutics aimed at reducing the skin inflammatory state. In this review, we discuss the current knowledge on the mechanisms of rosacea in general and of periocular skin-affecting disease in particular, identify key questions that remain to be answered in future research, and offer a disease model that can explain the key characteristics of this disease, with particular emphasis on a potential positive feedback loop that could explain both the acute and chronic features of rosacea.

酒渣鼻是一种常见的慢性皮肤病，主要影响 40 岁及以上的人群，目前无法治愈。当它影响眼睑和眼周皮肤时，会导致干眼症和潜在的角膜损伤。在过去十年中进行的研究揭示了导致皮肤过敏的潜在机制，并为开发旨在减少皮肤炎症状态的新型合理疗法提供了有希望的途径。在这篇综述中，我们讨论了目前关于红斑痤疮的一般机制，特别是眼周皮肤影响疾病的知识，确定了在未来研究中仍有待回答的关键问题，并提供了一个可以解释红斑痤疮关键特征的疾病模型。这种病，