Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive-compulsive disorder: Results from two pilot studies,Depression and Anxiety

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Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive-compulsive disorder: Results from two pilot studies
Depression and Anxiety ( IF 7.4 ) Pub Date : 2021-08-31 , DOI: 10.1002/da.23212
Thomas G Adams _{1,

2,

3} , Josh M Cisler _{4,

5} , Benjamin Kelmendi _{2,

3} , Jamilah R George _{2,

6} , Stephen A Kichuk ₂ , Christopher L Averill _{2,

3,

7,

8} , Alan Anticevic ₂ , Chadi G Abdallah _{2,

3,

7,

8} , Christopher Pittenger _{2,

9}

Affiliation

Exposed-based psychotherapy is a mainstay of treatment for obsessive-compulsive disorder (OCD) and anxious psychopathology. The medial prefrontal cortex (mPFC) and the default mode network (DMN), which is anchored by the mPFC, promote safety learning. Neuromodulation targeting the mPFC might augment therapeutic safety learning and enhance response to exposure-based therapies.

中文翻译：

针对内侧前额叶皮层的经颅直流电刺激可调节功能连接并增强强迫症的安全学习：两项初步研究的结果

基于暴露的心理治疗是治疗强迫症 (OCD) 和焦虑精神病理学的主要方法。内侧前额叶皮层 (mPFC) 和由 mPFC 锚定的默认模式网络 (DMN) 促进安全学习。针对 mPFC 的神经调节可能会增强治疗安全性学习并增强对基于暴露的疗法的反应。

更新日期：2021-08-31

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