Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled ¹⁹F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI.

中文翻译：

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过氧亚硝酸盐反应性 19F MRI 纳米探针对药物性肝损伤的深层组织实时成像

过氧亚硝酸盐是评估药物性肝损伤 (DILI) 的重要生物标志物，对药物的开发和使用至关重要。在此，我们报告了过氧亚硝酸盐响应性自组装¹⁹ F MRI 纳米探针的开发，它能够对经受氧化应激的 L02 细胞和患有 DILI 的活小鼠中的过氧亚硝酸盐进行敏感成像。