Inflammatory bowel disease includes ulcerative colitis (UC) and Crohn’s disease (CD) of unknown etiology. The expression of ATP-binding cassette (ABC) family proteins has been associated with drug resistance and development of UC. The cystic fibrosis transmembrane conductance regulator (CFTR) or also known as ABCC7 is involved in the inflammatory chronic response. The aim of this study was to evaluate the role of ABCC7/CFTR in UC patients and normal controls without inflammation. This is an exploratory, observational, and cross-sectional study that included a total of 62 patients with UC and normal controls. Gene expression of CFTR was measured by RT-PCR, and protein expression of CFTR was determined by western blot analysis. We found a significant downregulation of the CFTR gene expression in patients with active UC compared to normal controls without inflammation (); even the gene expression of CFTR was decreased in remission UC patients compared to normal controls without inflammation (). The CFTR gene expression was associated with the clinical course of UC and the protein expression of CFTR was decreased in active UC patients compared to normal controls without inflammation suggesting that this molecule might play a role in the inflammation in UC patients.

中文翻译：

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ABCC7/CFTR 表达与溃疡性结肠炎患者的临床病程相关

炎症性肠病包括病因不明的溃疡性结肠炎 (UC) 和克罗恩病 (CD)。ATP 结合盒 (ABC) 家族蛋白的表达与耐药性和 UC 的发展有关。囊性纤维化跨膜电导调节器 (CFTR) 或也称为 ABCC7 参与炎症慢性反应。本研究的目的是评估 ABCC7/CFTR 在 UC 患者和没有炎症的正常对照中的作用。这是一项探索性、观察性和横断面研究，共包括 62 名 UC 患者和正常对照。RT-PCR检测CFTR基因表达，Western blot分析CFTR蛋白表达。); 甚至与没有炎症的正常对照相比，缓解期 UC 患者中 CFTR 的基因表达也降低了（）。CFTR 基因表达与 UC 的临床病程相关，与没有炎症的正常对照相比，活动性 UC 患者中 CFTR 的蛋白质表达降低，表明该分子可能在 UC 患者的炎症中起作用。