Realizing a high-contrast anti-scattering light focusing by using a spatial light modulation such as a digital micromirror device (DMD) demands a robust optimizer in the process of wavefront shaping. Genetic algorithm (GA) as a common practice can easily be stuck into the inferior local minima. Here, we combined GA with encoding neighboring pixels of DMD to circumvent the inferior local minima. Simulations and experiments have demonstrated that our method could greatly increase the anti-scattering capability when compared with the conventional GA method. This work could be an important step towards deep tissue noninvasive optical imaging, optogenetics, and photodynamic therapy.

通过使用诸如数字微镜器件 (DMD) 之类的空间光调制来实现高对比度抗散射光聚焦，需要在波前整形过程中使用强大的优化器。遗传算法 (GA) 作为一种常见做法很容易陷入劣质局部最小值。在这里，我们将 GA 与编码 DMD 的相邻像素相结合，以规避劣质局部最小值。模拟和实验表明，与传统的 GA 方法相比，我们的方法可以大大提高抗散射能力。这项工作可能是朝着深部组织无创光学成像、光遗传学和光动力疗法迈出的重要一步。