Anti-epileptic drugs (AEDs) are the mainstay of epilepsy treatment but these may be a potential risk factor for behavioral disturbances particularly depression which requires treatment. In this study, the effect of antidepressant sertraline (SRT) in combination with AEDs sodium valproate (SV) and levetiracetam (LEV) on seizures, cognitive impairment and oxidative stress in rats was evaluated.

After administration of 24th injection of pentylenetetrazole (PTZ), 77.8% rats were kindled. Administration of SRT showed no protective effect on kindling development while SV was 100% protective. With LEV 42.9% were kindled. On combining SRT with SV or LEV 25% and 20% rats were kindled. A significant increase in latency to reach platform zone in Morris water maze(MWM), and increased transfer latencies in Elevated plus maze(EPM) was observed in PTZ kindled rats as compared to normal control on day 49 and when LEV was combined with SRT. In EPM test, however none of the drug treatments had any effect on transfer latencies except LEV pretreated kindled group. In Passive avoidance (PA) test, kindling was associated with a significant decrease in retention time(p = 0.018) while LEV and SV had no effect. The PTZ kindled rats showed significantly higher malondialdehyde(MDA) levels in brain hippocampus(p = 0.0286) while both SRT and SV were associated with significantly lower MDA levels as compared to kindled control group. In case of glutathione (GSH), kindling had no significant effect.

The use of sertraline for depression in persons with epilepsy on AEDs needs to be carefully evaluated and monitored due to likelihood of individual variation.

抗癫痫药物 (AED) 是癫痫治疗的中流砥柱，但它们可能是行为障碍的潜在危险因素，尤其是需要治疗的抑郁症。在这项研究中，评估了抗抑郁药舍曲林 (SRT) 与 AED 丙戊酸钠 (SV) 和左乙拉西坦 (LEV) 联合对大鼠癫痫发作、认知障碍和氧化应激的影响。

第24次戊四唑(PTZ)注射后，77.8%的大鼠被点燃。SRT 的施用对点燃发育没有保护作用，而 SV 具有 100% 的保护作用。LEV 42.9% 被点燃。在将 SRT 与 SV 或 LEV 结合时，点燃 25% 和 20% 的大鼠。在第 49 天和 LEV 与 SRT 组合时，与正常对照组相比，在 PTZ 点燃的大鼠中观察到，在 Morris 水迷宫 (MWM) 中到达平台区的潜伏期显着增加，并且在高架十字迷宫 (EPM) 中的转移潜伏期增加。然而，在 EPM 测试中，除 LEV 预处理点燃组外，其他药物治疗对转移潜伏期均无影响。在被动回避 (PA) 测试中，点燃与保留时间的显着减少相关 (p = 0.018)，而 LEV 和 SV 没有影响。与点燃的对照组相比，PTZ点燃的大鼠大脑海马中丙二醛（MDA）水平显着升高（p = 0.0286），而SRT和SV均与显着降低的MDA水平相关。在谷胱甘肽（GSH）的情况下，点燃没有显着影响。

由于个体差异的可能性，需要仔细评估和监测使用 AED 治疗癫痫患者的抑郁症。