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A disposable, wearable, flexible, stitched textile electrochemical biosensing platform
Biosensors and Bioelectronics ( IF 12.6 ) Pub Date : 2021-09-01 , DOI: 10.1016/j.bios.2021.113604
Andrew Piper 1 , Ingrid Öberg Månsson 1 , Shirin Khaliliazar 1 , Roman Landin 1 , Mahiar Max Hamedi 1
Affiliation  

Wearable sensors are a fast growing and exciting research area, the success of smart watches are a great example of the utility and demand for wearable sensing systems. The current state of the art routinely uses expensive and bulky equipment designed for long term use. There is a need for cheap and disposable wearable sensors to make single use measurements, primarily in the area of biomarker detection. Herein we report the ability to make cheap (0.22 USD/sensor), disposable, wearable sensors by stitching conductive gold coated threads into fabrics. These threads are easily functionalised with thiolate self-assembled monolayers which can be designed for the detection of a broad range of different biomarkers. This all textile sensing platform is ideally suited to be scaled up and has the added advantage of being stretchable with insignificant effect on the electrochemistry of the devices. As a proof of principle, the devices have been functionalised with a continuous glucose sensing system which was able to detect glucose in human sweat across the clinically relevant range (0.1-0.6 mM). The sensors have a sensitivity of 126 ± 14 nA/mM of glucose and a limit of detection of 301 ± 2 nM. This makes them ideally suited for biomarker detection in point-of-care sensing applications.



中文翻译:

一次性、可穿戴、灵活、缝合的纺织电化学生物传感平台

可穿戴传感器是一个快速发展且令人兴奋的研究领域,智能手表的成功是可穿戴传感系统实用性和需求的一个很好的例子。现有技术的当前状态通常使用设计用于长期使用的昂贵且笨重的设备。需要廉价且一次性的可穿戴传感器来进行一次性测量,主要是在生物标志物检测领域。在此,我们报告了通过将导电镀金线缝合到织物中来制造廉价(0.22 美元/传感器)、一次性、可穿戴传感器的能力。这些线很容易用硫醇盐自组装单层进行功能化,可设计用于检测各种不同的生物标志物。这种全纺织品传感平台非常适合按比例放大,并且具有可拉伸的附加优势,对设备的电化学影响微不足道。作为原理证明,这些设备已使用连续葡萄糖传感系统进行功能化,该系统能够在临床相关范围 (0.1-0.6 mM) 内检测人体汗液中的葡萄糖。传感器的灵敏度为 126 ± 14 nA/mM 葡萄糖,检测限为 301 ± 2 nM。这使得它们非常适用于床旁传感应用中的生物标志物检测。传感器的灵敏度为 126 ± 14 nA/mM 葡萄糖,检测限为 301 ± 2 nM。这使得它们非常适用于床旁传感应用中的生物标志物检测。传感器的灵敏度为 126 ± 14 nA/mM 葡萄糖,检测限为 301 ± 2 nM。这使得它们非常适用于床旁传感应用中的生物标志物检测。

更新日期:2021-09-01
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