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Ti3C2 MXene anchors CuAu-LDH multifunctional two-dimensional nanomaterials for dual-mode detection of CEA in electrochemical immunosensors
Bioelectrochemistry ( IF 5 ) Pub Date : 2021-09-01 , DOI: 10.1016/j.bioelechem.2021.107943
Mengmeng Zhang 1 , Lisha Mei 1 , Li Zhang 1 , Xiao Wang 1 , Xiaochen Liao 1 , Xiuwen Qiao 1 , Chenglin Hong 1
Affiliation  

Electrochemical immunoassays are commonly used to detect biomarkers and Ti3C2 MXene anchored CuAu-LDH two-dimensional hydroxide heterojunctions for dual-mode electrochemical immunosensors were fabricated in this work. Layered double hydroxides have a large surface area, high chemical stability, tunable metal composition and interchangeable anions, however, the insulating nature of LDH further limits its catalytic performance. For this reason, Ti3C2 Mxenes were introduced to improve this problem. 2D layers of Ti3C2 Mxenes with large specific surface area and excellent conductivity have been well proven and widely used. And the surface of Ti3C2 Mxenes (due to the presence of abundant surface functional groups), will facilitate the anchoring of metal ions and the nucleation of LDH. In addition, its excellent electrical conductivity will facilitate the electron transfer between Cu2+ and Cu+. The immunosensor not only showed a heavy square wave voltammetry (SWV) signal. It also exhibited high electrocatalytic activity for H2O2 redox reactions and improves the sensitivity of the Ampere Current (i-t) detection. The CEA immunosensor developed in this study showed a wide linear response (0.0001–80 ng/mL) and the lowest detection limits (SWV: 33.6 fg/mL and i-t: 45.4 fg/mL S/N = 3). The results confirmed the excellent analytical capability of the immunosensor.



中文翻译:

Ti3C2 MXene 锚定 CuAu-LDH 多功能二维纳米材料用于电化学免疫传感器中 CEA 的双模式检测

电化学免疫测定通常用于检测生物标志物,并且在这项工作中制造了用于双模式电化学免疫传感器的 Ti 3 C 2 MXene 锚定的 CuAu-LDH 二维氢氧化物异质结。层状双氢氧化物具有较大的表面积、较高的化学稳定性、可调节的金属成分和可互换的阴离子,然而,LDH的绝缘性进一步限制了其催化性能。为此,引入了Ti 3 C 2 Mxenes 来改善这个问题。Ti 3 C 2 Mxene 的二维层具有大的比表面积和优异的导电性,已得到充分证明并得到广泛应用。和Ti 3 C 2的表面Mxenes(由于存在丰富的表面官能团)将促进金属离子的锚定和 LDH 的成核。此外,其优异的导电性将促进Cu 2+和Cu +之间的电子转移。免疫传感器不仅显示出重方波伏安 (SWV) 信号。它还表现出对 H 2 O 2氧化还原反应的高电催化活性,并提高了安培电流 (it) 检测的灵敏度。本研究开发的 CEA 免疫传感器显示出宽线性响应 (0.0001–80 ng/mL) 和最低检测限 (SWV: 33.6 fg/mL 和它: 45.4 fg/mL S/N = 3)。结果证实了免疫传感器的出色分析能力。

更新日期:2021-09-09
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