Lipocalin-2 (LCN2) is an inflammatory mediator best known for its role as an innate acute-phase protein. LCN2 mediates the innate immune response to pathogens by sequestering iron, thereby inhibiting pathogen growth. Though LCN2 and its bacteriostatic properties are well studied, other LCN2 functions in the immune response to inflammatory stimuli are less well understood, such as its role as a chemoattractant and involvement in the regulation of cell migration and apoptosis. In the lungs, most studies thus far investigating the role of LCN2 in the immune response have looked at pathogenic inflammatory stimuli. Here, we compile data that explore the role of LCN2 in the immune response to various inflammatory stimuli in an effort to differentiate between protective versus detrimental roles of LCN2.

中文翻译：

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脂质运载蛋白 2 介导的肺部炎症作用的综合评价

Lipocalin-2 (LCN2) 是一种炎症介质，以其作为先天急性期蛋白的作用而闻名。LCN2通过螯合铁介导对病原体的先天免疫反应，从而抑制病原体的生长。尽管 LCN2 及其抑菌特性得到了很好的研究，但 LCN2 在对炎症刺激的免疫反应中的其他功能却鲜为人知，例如它作为化学引诱剂的作用以及参与调节细胞迁移和凋亡。在肺部，迄今为止调查 LCN2 在免疫反应中的作用的大多数研究都着眼于致病性炎症刺激。在这里，我们汇编了探索 LCN2 在对各种炎症刺激的免疫反应中的作用的数据，以努力区分 LCN2 的保护作用和有害作用。