Central-Andean Ecosystems (between 2000 and 6000 m above sea level (masl) are typical arid-to-semiarid environments suffering from the highest total solar and ultraviolet-B radiation on the planet but displaying numerous salt flats and shallow lakes. Andean microbial ecosystems isolated from these environments are of exceptional biodiversity enduring multiple severe conditions. Furthermore, the polyextremophilic nature of the microbes in such ecosystems indicates the potential for biotechnological applications. Within this context, the study undertaken used genome mining, physiological and microscopical characterization to reveal the multiresistant profile of Nesterenkonia sp. Act20, an actinobacterium isolated from the soil surrounding Lake Socompa, Salta, Argentina (3570 masl). Ultravioet-B, desiccation, and copper assays revealed the strain’s exceptional resistance to all these conditions. Act20’s genome presented coding sequences involving resistance to antibiotics, low temperatures, ultraviolet radiation, arsenic, nutrient-limiting conditions, osmotic stress, low atmospheric-oxygen pressure, heavy-metal stress, and toxic fluoride and chlorite. Act20 can also synthesize proteins and natural products such as an insecticide, bacterial cellulose, ectoine, bacterial hemoglobin, and even antibiotics like colicin V and aurachin C. We also found numerous enzymes for animal- and vegetal-biomass degradation and applications in other industrial processes. The resilience of Act20 and its biotechnologic potential were thoroughly demonstrated in this work.

安第斯中部生态系统（海拔 2000 至 6000 米（masl）是典型的干旱至半干旱环境，受地球上最高的太阳和紫外线 B 辐射总量影响，但显示出众多盐滩和浅湖。安第斯微生物生态系统从这些环境中分离出来的生物具有特殊的生物多样性，可以承受多种恶劣条件。此外，这种生态系统中微生物的多极端性质表明了生物技术应用的潜力。在此背景下，所进行的研究使用基因组挖掘、生理学和显微镜表征来揭示多抗性内斯特伦科尼亚简介sp。Act20，一种从阿根廷萨尔塔索康帕湖周围土壤中分离出的放线菌 (3570 masl)。紫外线-B、干燥和铜化验揭示了该菌株对所有这些条件的异常抵抗力。Act20 的基因组呈现的编码序列涉及对抗生素、低温、紫外线辐射、砷、营养限制条件、渗透胁迫、低大气氧压力、重金属胁迫以及有毒氟化物和亚氯酸盐的抗性。Act20 还可以合成蛋白质和天然产物，例如杀虫剂、细菌纤维素、四氢嘧啶、细菌血红蛋白，甚至是大肠菌素 V 和 aurachin C 等抗生素。我们还发现了许多用于动物和植物生物质降解的酶以及在其他工业过程中的应用.