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Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
Journal of Ophthalmic Inflammation and Infection Pub Date : 2021-09-01 , DOI: 10.1186/s12348-021-00259-x
Amravi Shah 1 , Sneha Giridhar 2 , Gazal Patnaik 1 , Radhika Mhatre 3 , Dipankar Das 4 , M K Janani 5 , Anita Mahadevan 3 , Jyotirmay Biswas 1
Affiliation  

Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings.

中文翻译:

一例 Eales 病去核标本的组织病理学、免疫组织化学和分子生物学研究

Eales 病是一种以视网膜炎症、缺血和新生血管形成为特征的视网膜血管炎。本病的确切发病机制尚未查明。我们介绍了一名 29 岁男性,双眼被诊断患有 Eales 病,并伴有持续性眼内炎症。摘除右眼进行组织病理学检查、免疫组织化学和分枝杆菌结核 DNA 分子生物学研究。我们的研究表明,Eales 病可能是由分枝杆菌 TB DNA 引发的 T 细胞介导的疾病。需要进一步的研究来证实我们的发现。
更新日期:2021-09-01
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