当前位置: X-MOL 学术Clin. Phytosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Impact of Althaea Officinalis extract in patients with atopic eczema: a double-blind randomized controlled trial
Clinical Phytoscience Pub Date : 2021-09-01 , DOI: 10.1186/s40816-021-00306-z
Negar Khalighi 1 , Farahzad Jabbari-Azad 1 , Maral Barzegar-Amini 1 , Jalil Tavakkol-Afshari 2 , Pouran Layegh 3 , Roshanak Salari 4
Affiliation  

Althaea Officinalis introduced as an emerging anti-inflammatory agent with immunomodulatory effects that may suppress the symptoms of atopic eczema. In this study, we aimed to investigate the impact of liposomal formulation of Althaea Officinalis flower extract compared with steroids for atopic eczema treatment. In this randomized, double-blind controlled trial phase II, forty patients with moderate to severe allergic atopic eczema confirmed by skin prick test were enrolled in the study from October 2018 to January 2019. Steroids on the lesions of the left side of the body and topical Althaea Officinalis extract (intervention) or eucerin as a topical placebo on the lesions of the right side of the body were tested. SCORAD (SCORing Atopic Dermatitis) was assessed at the baseline, and two, and four weeks after completing the trial. Data were analyzed by SPSS version 22. In the active treatment group, after two weeks, the SCORAD was significantly lower in the left side (recovery with steroid treatment) (p < 0.001), and after 4 weeks the SCORAD was lower on both sides, and there were no significant differences between two sides (similarity between Althaea Officinalis and steroid effects). In the control group, the SCORAD score was significantly lower on the left side (steroid) after two and four weeks (p < 0.001). There was no side effect and reaction to drugs. Considering the potential side effects of steroids, and the similar efficacy of Althaea Officinalis flower extract, using this component may be accompanied by higher benefits in patients with atopic eczema. IRCT2016102323235N5 .

中文翻译:

Althaea Officinalis 提取物对特应性湿疹患者的影响:一项双盲随机对照试验

Althaea Officinalis 作为一种新兴的抗炎剂推出,具有免疫调节作用,可以抑制特应性湿疹的症状。在这项研究中,我们旨在研究与类固醇相比,山药花提取物的脂质体制剂对特应性湿疹治疗的影响。在这项随机、双盲对照试验 II 期中,2018 年 10 月至 2019 年 1 月,经皮肤点刺试验确认的 40 名中重度过敏性特应性湿疹患者入组。在身体右侧的病变上测试了外用 Althaea Officinalis 提取物(干预)或优色林作为外用安慰剂。SCORAD(特应性皮炎评分)在基线、完成试验后两周和四周进行评估。数据采用SPSS 22版进行分析。 在积极治疗组中,两周后左侧SCORAD显着降低(类固醇治疗恢复)(p < 0.001),4周后两侧SCORAD均降低,并且两侧没有显着差异(Althaea Officinalis 和类固醇作用之间的相似性)。在对照组中,2 周和 4 周后左侧(类固醇)的 SCORAD 评分显着降低(p < 0.001)。没有副作用和对药物的反应。考虑到类固醇的潜在副作用,以及 Althaea Officinalis 花提取物的类似功效,使用该成分可能会为特应性湿疹患者带来更高的益处。IRCT2016102323235N5。左侧 SCORAD 显着降低(激素治疗恢复)(p < 0.001),4 周后两侧 SCORAD 降低,两侧无显着差异(Althaea Officinalis 和类固醇作用相似) )。在对照组中,2 周和 4 周后左侧(类固醇)的 SCORAD 评分显着降低(p < 0.001)。没有副作用和对药物的反应。考虑到类固醇的潜在副作用,以及 Althaea Officinalis 花提取物的类似功效,使用该成分可能会为特应性湿疹患者带来更高的益处。IRCT2016102323235N5。左侧 SCORAD 显着降低(激素治疗恢复)(p < 0.001),4 周后两侧 SCORAD 降低,两侧无显着差异(Althaea Officinalis 和类固醇作用相似) )。在对照组中,2 周和 4 周后左侧(类固醇)的 SCORAD 评分显着降低(p < 0.001)。没有副作用和对药物的反应。考虑到类固醇的潜在副作用,以及 Althaea Officinalis 花提取物的类似功效,使用该成分可能会为特应性湿疹患者带来更高的益处。IRCT2016102323235N5。并且两者之间没有显着差异(Althaea Officinalis 和类固醇作用之间的相似性)。在对照组中,2 周和 4 周后左侧(类固醇)的 SCORAD 评分显着降低(p < 0.001)。没有副作用和对药物的反应。考虑到类固醇的潜在副作用,以及 Althaea Officinalis 花提取物的类似功效,使用该成分可能会为特应性湿疹患者带来更高的益处。IRCT2016102323235N5。并且两者之间没有显着差异(Althaea Officinalis 和类固醇作用之间的相似性)。在对照组中,2 周和 4 周后左侧(类固醇)的 SCORAD 评分显着降低(p < 0.001)。没有副作用和对药物的反应。考虑到类固醇的潜在副作用,以及 Althaea Officinalis 花提取物的类似功效,使用该成分可能会为特应性湿疹患者带来更高的益处。IRCT2016102323235N5。和山药花提取物的相似功效,使用该成分可能伴随着特应性湿疹患者的更高益处。IRCT2016102323235N5。和山药花提取物的相似功效,使用该成分可能伴随着特应性湿疹患者的更高益处。IRCT2016102323235N5。
更新日期:2021-09-01
down
wechat
bug