Multifunctional self-healing hydrogels have recently attracted considerable interest in biomedical applications owing to their diverse properties, including self-healing, adhesion, conduction, antibacterial, and stimulus-response, which can meet various application requirements, ranging from wound dressings and delivery vehicles to the production of scaffolds for tissue repair and regeneration. As a natural polycationic polysaccharide with good biocompatibility, chitosan is widely used in hydrogel formation as there are many amino and hydroxyl groups along the chains that can actively participate in various physical effects and chemical reactions, which enable it to construct self-healing hydrogels and fulfill multiple functions. In this review, the formation of chitosan-based self-healing hydrogels and the related self-healing mechanism are summarized, including Schiff base, metal coordination, ionic and hydrogen bonds, hydrophobic and host–guest interactions, with a focus on the strategies for their multi-functionalization. In the last section, the applications of the chitosan-based self-healing hydrogels in the fields of wound dressings, delivery vehicles, scaffolds, and biological sensors are discussed. Overall, it is highly expected that this review could provide an insight into the prospective development of multifunctional self-healing hydrogels for biomedical applications.

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用于生物医学应用的多功能壳聚糖基自愈水凝胶的进展

多功能自修复水凝胶最近在生物医学应用中引起了相当大的兴趣，因为它们具有多种特性，包括自修复、粘附、传导、抗菌和刺激反应，可以满足从伤口敷料和递送载体到各种应用需求。生产用于组织修复和再生的支架。壳聚糖作为一种具有良好生物相容性的天然聚阳离子多糖，由于其链上有许多氨基和羟基，可以积极参与各种物理作用和化学反应，使其能够构建自修复水凝胶并实现水凝胶的形成，因此被广泛用于水凝胶的形成多种功能。在本次审查中，总结了壳聚糖基自修复水凝胶的形成及其相关自修复机制，包括席夫碱、金属配位、离子和氢键、疏水和主客体相互作用，重点介绍了其多功能化的策略. 最后一节讨论了壳聚糖基自愈水凝胶在伤口敷料、运载工具、支架和生物传感器等领域的应用。总体而言，人们高度期望这篇综述可以深入了解用于生物医学应用的多功能自愈水凝胶的前瞻性发展。讨论了壳聚糖基自愈水凝胶在伤口敷料、运载工具、支架和生物传感器领域的应用。总体而言，人们高度期望这篇综述可以深入了解用于生物医学应用的多功能自愈水凝胶的前瞻性发展。讨论了壳聚糖基自愈水凝胶在伤口敷料、运载工具、支架和生物传感器领域的应用。总体而言，人们高度期望这篇综述可以深入了解用于生物医学应用的多功能自愈水凝胶的前瞻性发展。