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Ultrasound-Enabled Therapeutic Delivery and Regenerative Medicine: Physical and Biological Perspectives
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2021-08-30 , DOI: 10.1021/acsbiomaterials.1c00276 Kahkashan Bansal 1 , Chandan Kumar Jha 2 , Dhiraj Bhatia 1, 3 , Himanshu Shekhar 2, 3
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2021-08-30 , DOI: 10.1021/acsbiomaterials.1c00276 Kahkashan Bansal 1 , Chandan Kumar Jha 2 , Dhiraj Bhatia 1, 3 , Himanshu Shekhar 2, 3
Affiliation
The role of ultrasound in medicine and biological sciences is expanding rapidly beyond its use in conventional diagnostic imaging. Numerous studies have reported the effects of ultrasound on cellular and tissue physiology. Advances in instrumentation and electronics have enabled successful in vivo applications of therapeutic ultrasound. Despite path breaking advances in understanding the biophysical and biological mechanisms at both microscopic and macroscopic scales, there remain substantial gaps. With the progression of research in this area, it is important to take stock of the current understanding of the field and to highlight important areas for future work. We present herein key developments in the biological applications of ultrasound especially in the context of nanoparticle delivery, drug delivery, and regenerative medicine. We conclude with a brief perspective on the current promise, limitations, and future directions for interfacing ultrasound technology with biological systems, which could provide guidance for future investigations in this interdisciplinary area.
中文翻译:
超声治疗递送和再生医学:物理和生物学视角
超声波在医学和生物科学中的作用正在迅速扩大,超出了其在传统诊断成像中的使用。许多研究报告了超声波对细胞和组织生理学的影响。仪器和电子设备的进步使体内试验取得成功治疗性超声的应用。尽管在理解微观和宏观尺度的生物物理和生物机制方面取得了突破性进展,但仍然存在巨大差距。随着该领域研究的进展,重要的是评估当前对该领域的理解并突出未来工作的重要领域。我们在此介绍了超声生物应用的关键发展,特别是在纳米颗粒递送、药物递送和再生医学的背景下。最后,我们简要介绍了超声技术与生物系统接口的当前前景、局限性和未来方向,这可以为该跨学科领域的未来研究提供指导。
更新日期:2021-09-13
中文翻译:
超声治疗递送和再生医学:物理和生物学视角
超声波在医学和生物科学中的作用正在迅速扩大,超出了其在传统诊断成像中的使用。许多研究报告了超声波对细胞和组织生理学的影响。仪器和电子设备的进步使体内试验取得成功治疗性超声的应用。尽管在理解微观和宏观尺度的生物物理和生物机制方面取得了突破性进展,但仍然存在巨大差距。随着该领域研究的进展,重要的是评估当前对该领域的理解并突出未来工作的重要领域。我们在此介绍了超声生物应用的关键发展,特别是在纳米颗粒递送、药物递送和再生医学的背景下。最后,我们简要介绍了超声技术与生物系统接口的当前前景、局限性和未来方向,这可以为该跨学科领域的未来研究提供指导。