Cerebral aneurysms are vascular lesions caused by the biomechanical failure of the vessel wall due to hemodynamic stress and inflammation. Aneurysmal rupture results in subarachnoid hemorrhage often leading to death or disability. Current treatment options include open surgery and minimally invasive endovascular options aimed at secluding the aneurysm from the circulation. Cerebral aneurysm embolization with appropriate materials is a therapeutic approach to prevent rupture and the resultant clinical sequelae. Metallic platinum coils are a typical, practical option to embolize cerebral aneurysms. However, the development of an alternative treatment modality is of interest because of poor occlusion permanence, coil migration, and coil compaction. Moreover, minimizing the implanted foreign materials during therapy is of importance not just to patients, but also to clinicians in the event an open surgical approach has to be pursued in the future. Polymeric injectable hydrogels have been investigated for transcatheter embolization and cell therapy with the potential for permanent aneurysm repair. This review focuses on how the combination of injectable embolic biomaterials and cell therapy may achieve minimally invasive remodeling of a degenerated cerebral artery with promise for superior outcomes in treatment of this devastating disease.

脑动脉瘤是血管壁因血流动力学应力发生生物力学失效而引起的血管病变和炎症。动脉瘤破裂导致蛛网膜下腔出血，通常会导致死亡或残疾。目前的治疗选择包括开放手术和微创血管内选择，旨在将动脉瘤从循环中隔离。用合适的材料栓塞脑动脉瘤是一种预防破裂和由此产生的临床后遗症的治疗方法。金属铂线圈是栓塞脑动脉瘤的典型实用选择。然而，由于闭塞持久性差、线圈迁移和线圈压实，替代治疗方式的发展是令人感兴趣的。此外，在治疗过程中尽量减少植入的异物不仅对患者很重要，而且对临床医生在未来必须追求开放式手术方法的情况下也很重要。聚合物可注射水凝胶已被研究用于经导管栓塞和细胞治疗，具有永久性动脉瘤修复的潜力。本综述重点介绍了可注射栓塞的组合生物材料和细胞疗法可以实现退化脑动脉的微创重塑，有望在这种破坏性疾病的治疗中取得更好的效果。