Phytochemical investigation on the dried fruits of Casearia grewiifolia led to the identification of 10 new salicinoyl quinic acid derivatives (1–10), a new benzoyl quinic acid (11), and two known compounds (12 and 13). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E₂ (PGE₂) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE₂ production with IC₅₀ values of 20.5 and 28.8 μM, respectively.

中文翻译：

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木瓜果实中水杨酰基奎尼酸及其前列腺素E2的抑制活性

上的干果植物化学物质调查嘉赐grewiifolia导致的10个新的salicinoyl奎尼酸衍生物（标识1 - 10），一个新的苯甲酰奎尼酸（11），以及两个公知的化合物（12和13）。通过解释包括 HMBC 和 EXSIDE 在内的 1D 和 2D NMR 光谱数据以及用于糖单元分析的化学方法，阐明了新化合物的结构。评估了所有分离株对紫外线 B (UVB) 照射的 HaCat 角质形成细胞中前列腺素 E ₂ (PGE ₂ ) 产生的抑制活性。在测试的分离株中，化合物6和发现12抑制 PGE _{2 的}产生，IC ₅₀值分别为 20.5 和 28.8 μM。