The incidence of coronary heart disease is increasing yearly. Coronary artery bypass graft (CABG) is an important surgical method for the treatment of coronary heart disease. The vein grafts in CABG surgery mostly use saphenous vein, but restenosis of the graft frequently occurs, and has become an urgent clinical problem. In this study, we produced a UV-curable Hydroxyethyl Methacrylate (HEMA) gel containing Bletilla striata, and compared its tensile strength and expansibility to that of human vessels, showing that the film has good physical properties. Through cell experiments, we proved that film has no effect on cell proliferation, migration, apoptosis, and DNA damage. In addition, we placed the film under the skin of mice to measure inflammation-related cells and factors, and found that it did not trigger the body's immune response. After that, we designed a rat vein graft model to simulate the pathological changes of the vein graft vessel after CABG. The film had a good inhibitory effect on the restenosis of vein graft vessels in the rat model. Finally, analysis of the expression levels of proteins involved in the proliferation and migration indicated that the gel can effectively inhibit these processes in smooth muscle cells in the graft vein. In conclusion, this study has successfully produced a UV-curable HEMA gel containing B. striata that could effectively inhibit the restenosis of vein grafts.

冠心病的发病率逐年增加。冠状动脉旁路移植术（CABG）是治疗冠心病的重要手术方法。CABG手术中的静脉移植多采用大隐静脉，但移植物再狭窄时常发生，已成为临床急需解决的问题。在这项研究中，我们生产了一种紫外线固化的甲基丙烯酸羟乙酯 (HEMA) 凝胶，其中含有白芨，并将其拉伸强度和膨胀性与人体血管进行比较，表明该薄膜具有良好的物理性能。通过细胞实验，我们证明薄膜对细胞增殖、迁移、凋亡和DNA损伤没有影响。此外，我们将薄膜置于小鼠皮下，测量与炎症相关的细胞和因子，发现它并没有触发机体的免疫反应。之后，我们设计了大鼠静脉移植模型来模拟CABG术后静脉移植血管的病理变化。该膜对大鼠模型静脉移植血管再狭窄有很好的抑制作用。最后，对参与增殖和迁移的蛋白质表达水平的分析表明，凝胶可以有效抑制移植静脉平滑肌细胞中的这些过程。综上所述，B. striata能有效抑制移植静脉再狭窄。