Brain tumours are masses of abnormal cells that can grow in an uncontrolled way in the brain. There are different types of malignant brain tumours. Gliomas are malignant brain tumours that grow from glial cells and are identified as astrocytoma, oligodendroglioma, and ependymoma. We study a mathematical model that describes glia-neuron interaction, glioma, and chemotherapeutic agent. In this work, we consider drug sensitive and resistant glioma cells. We show how continuous and pulsed chemotherapy can kill glioma cells with a minimal loss of neurons.

中文翻译：

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具有耐药性的脑肿瘤生长的数学模型

脑肿瘤是大量异常细胞，可以在大脑中以不受控制的方式生长。有不同类型的恶性脑肿瘤。神经胶质瘤是从神经胶质细胞生长的恶性脑肿瘤，被鉴定为星形细胞瘤、少突胶质细胞瘤和室管膜瘤。我们研究了一个描述神经胶质-神经元相互作用、神经胶质瘤和化疗药物的数学模型。在这项工作中，我们考虑了药物敏感和抗性神经胶质瘤细胞。我们展示了连续和脉冲化疗如何以最小的神经元损失杀死神经胶质瘤细胞。