Aging is associated with the development of disease. Periodontal disease is one of the many diseases and conditions that increase in prevalence with age. In addition to the traditional focus on individual age-related conditions, there is now a greater recognition that multisystem conditions such as frailty play an important role in the health of older populations. Frailty is a clinical condition in older adults that increases the risk of adverse health outcomes. Both frailty and periodontal disease are common chronic conditions in older populations and share several risk factors. There is likely a bidirectional relationship between periodontal disease and frailty. Comorbid systemic diseases, poor physical functioning, and limited ability to self-care in frail older people have been implicated as underlying the association between frailty and periodontal disease. In addition, both frailty and periodontal disease also have strong associations with inflammatory dysregulation and other age-related pathophysiologic changes that may similarly underlie their development and progression. Investigating age-related changes in immune cells that regulate inflammation may lead to a better understanding of age-related disease and could lead to therapeutic targets for the improved management of frailty and periodontal disease.

中文翻译：

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衰弱、衰老和牙周病：基本生物学考虑

衰老与疾病的发展有关。牙周病是随年龄增长而增加的许多疾病和病症之一。除了传统上关注个体与年龄相关的疾病外，现在人们更加认识到虚弱等多系统疾病在老年人群的健康中发挥着重要作用。虚弱是老年人的一种临床状况，会增加不良健康结果的风险。衰弱和牙周病都是老年人常见的慢性病，​​并且有几个共同的风险因素。牙周病和衰弱之间可能存在双向关系。合并全身性疾病，身体机能不佳，体弱的老年人自我保健能力有限被认为是虚弱与牙周病之间关联的潜在原因。此外，衰弱和牙周病也与炎症失调和其他与年龄相关的病理生理变化密切相关，这些变化可能同样是其发展和进展的基础。研究调节炎症的免疫细胞中与年龄相关的变化可能会导致更好地了解与年龄相关的疾病，并可能导致改善衰弱和牙周病管理的治疗目标。