Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeth. Severe periodontitis is highly prevalent—affecting 10%-15% of adults—and carries several negative comorbidities, thus reducing quality of life. Although a clear relationship exists between severity of obesity and incidence of periodontal disease, the biologic mechanisms that support this link are incompletely understood. In this conceptual appraisal, a new “two-hit” model is presented to explain obesity-exacerbated periodontal bone loss. This proposed model recognizes a previously unappreciated aspect of myeloid-derived suppressor cell population expansion, differentiation, and activity that can participate directly in periodontal bone loss, providing new mechanistic and translational perspectives.

中文翻译：

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肥胖相关牙周病中的髓源性抑制细胞：一个概念模型

牙周炎是一种常见的慢性炎症性疾病，其特征是牙齿的支撑结构被破坏。严重的牙周炎非常普遍——影响 10%-15% 的成年人——并伴有多种负面合并症，从而降低生活质量。尽管肥胖的严重程度与牙周病的发病率之间存在明确的关系，但支持这种联系的生物学机制尚不完全清楚。在这个概念评估中，提出了一种新的“两次打击”模型来解释肥胖加剧的牙周骨质流失。这个提出的模型认识到了髓源性抑制细胞群扩增、分化和活动的一个以前未被重视的方面，它可以直接参与牙周骨丢失，提供了新的机制和转化观点。