Ischemic stroke is one of the main causes of high morbidity, mortality, and disability worldwide; however, the treatment methods are limited and do not always achieve satisfactory results. The pathogenesis of ischemic stroke is complex, defined by multiple mechanisms; among them, programmed death of neuronal cells plays a significant role. Ferroptosis is a novel type of regulated cell death characterized by iron redistribution or accumulation and increased lipid peroxidation in the membrane. Ferroptosis is implicated in many pathological conditions, such as cancer, neurodegenerative diseases, and ischemia-reperfusion injury. In this review, we summarize current research findings on ferroptosis, including possible molecular mechanisms and therapeutic applications of ferroptosis regulators, with a focus on the involvement of ferroptosis in the pathogenesis and treatment of ischemic stroke. Understanding the role of ferroptosis in ischemic stroke will throw some light on the development of methods for diagnosis, treatment, and prevention of this devastating disease.

缺血性中风是全世界高发病率、死亡率和残疾的主要原因之一；然而，治疗方法有限，并不总能取得令人满意的效果。缺血性中风的发病机制复杂，由多种机制定义；其中，神经元细胞的程序性死亡起着重要作用。铁死亡是一种新型受调控的细胞死亡，其特征在于铁的重新分布或积累以及膜中脂质过氧化的增加。铁死亡与许多病理状况有关，例如癌症、神经退行性疾病和缺血再灌注损伤。在这篇综述中，我们总结了当前关于铁死亡的研究成果，包括可能的分子机制和铁死亡调节剂的治疗应用，重点关注铁死亡在缺血性卒中的发病机制和治疗中的作用。了解铁死亡在缺血性中风中的作用将为开发诊断、治疗和预防这种破坏性疾病的方法提供一些启示。