Suspected non-Alzheimer’s disease pathophysiology (SNAP) is a biomarker-based concept that underlying etiology has not been completely understood. Refers to a group of individuals that are negative for amyloid biomarkers and positive for p-Tau and/or neurodegeneration. SNAP causes great research interest because it is not clear if they have a different biological basis from Alzheimer's disease (AD), or are in an early stage of AD itself. The pathological processes behind SNAP need to be clarified. This mini-review aims to summarize the main characteristics of SNAP, besides reporting challenges and promising biomarkers related to the concept.

疑似非阿尔茨海默病病理生理学 (SNAP) 是一个基于生物标志物的概念，其潜在病因尚未完全了解。指对淀粉样蛋白生物标志物呈阴性而对 p-Tau 和/或神经变性呈阳性的一组个体。SNAP 引起了极大的研究兴趣，因为尚不清楚它们是否具有与阿尔茨海默病 (AD) 不同的生物学基础，或者是否处于 AD 本身的早期阶段。SNAP 背后的病理过程需要澄清。除了报告与该概念相关的挑战和有希望的生物标志物外，该小型评论旨在总结 SNAP 的主要特征。