Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, plays a critical role in susceptibility to environmental allergens. House dust mite allergy occurs more commonly than any other type of allergy among Egyptian asthmatic patients. To assess the relation between serum zonulin level as a marker of increased intestinal permeability and the severity of house dust mite allergic asthma. A case–control study which included 48 patients with house dust mite allergic asthma and 48 healthy control subjects attending the Allergy and Immunology Unit, Microbiology and Immunology Department, Faculty of Medicine, Zagazig University. A statistically significant difference was detected between the two studied groups with respect to serum IgE and serum zonulin levels (p ˂ 0.001 and ˂ 0.001, respectively). The mean serum zonulin was equal to 258.3 ± 153.01 ng/ml in the asthmatic group and 80 ± 13 ng/ml in the control group. Serum zonulin level significantly increased with the increase of asthma severity (p ˂ 0.001). The cut off value of serum zonulin was ≥ 198 ng/ml, and the area under the curve was 0.76. It displayed sensitivity equal to 80% and specificity equal to 71.4%. Its negative predictive value was equal to 83.3%. Intestinal barrier dysfunction contributes to the pathogenesis of allergic asthma. Serum zonulin level reflects an increase in intestinal permeability. Zonulin acts as prognostic factor of severity in asthma. Correction of the gut barrier defect may have a potential positive prognostic effect in asthma.

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血清zonulin水平与屋尘螨过敏性哮喘严重程度的相关性

由于哮喘患者暴露于抗原或由于屏障缺陷，肠道通透性增加在对环境过敏原的易感性中起着关键作用。在埃及哮喘患者中，屋尘螨过敏比任何其他类型的过敏更常见。评估作为肠道通透性增加标志物的血清 zonulin 水平与屋尘螨过敏性哮喘严重程度之间的关系。一项病例对照研究，包括 48 名屋尘螨过敏性哮喘患者和 48 名健康对照受试者，他们参加了 Zagazig 大学医学院微生物学和免疫学系过敏和免疫学组。在血清 IgE 和血清 zonulin 水平方面，检测到两个研究组之间存在统计学显着差异（p ˂ 0.001 和 ˂ 0.001，分别）。哮喘组的平均血清 zonulin 等于 258.3 ± 153.01 ng/ml，对照组为 80 ± 13 ng/ml。随着哮喘严重程度的增加，血清 zonulin 水平显着增加（p ˂ 0.001）。血清zonulin的临界值≥198 ng/ml，曲线下面积为0.76。它显示出等于 80% 的灵敏度和等于 71.4% 的特异性。其阴性预测值等于 83.3%。肠道屏障功能障碍有助于过敏性哮喘的发病机制。血清 zonulin 水平反映了肠道通透性的增加。Zonulin 作为哮喘严重程度的预后因素。纠正肠道屏障缺陷可能对哮喘有潜在的积极预后影响。哮喘组为 01 ng/ml，对照组为 80 ± 13 ng/ml。随着哮喘严重程度的增加，血清 zonulin 水平显着增加（p ˂ 0.001）。血清zonulin的临界值≥198 ng/ml，曲线下面积为0.76。它显示出等于 80% 的灵敏度和等于 71.4% 的特异性。其阴性预测值等于 83.3%。肠道屏障功能障碍有助于过敏性哮喘的发病机制。血清 zonulin 水平反映了肠道通透性的增加。Zonulin 作为哮喘严重程度的预后因素。纠正肠道屏障缺陷可能对哮喘有潜在的积极预后影响。哮喘组为 01 ng/ml，对照组为 80 ± 13 ng/ml。随着哮喘严重程度的增加，血清 zonulin 水平显着增加（p ˂ 0.001）。血清zonulin的临界值≥198 ng/ml，曲线下面积为0.76。它显示出等于 80% 的灵敏度和等于 71.4% 的特异性。其阴性预测值等于 83.3%。肠道屏障功能障碍有助于过敏性哮喘的发病机制。血清 zonulin 水平反映了肠道通透性的增加。Zonulin 作为哮喘严重程度的预后因素。纠正肠道屏障缺陷可能对哮喘有潜在的积极预后影响。曲线下面积为0.76。它显示出等于 80% 的灵敏度和等于 71.4% 的特异性。其阴性预测值等于 83.3%。肠道屏障功能障碍有助于过敏性哮喘的发病机制。血清 zonulin 水平反映了肠道通透性的增加。Zonulin 作为哮喘严重程度的预后因素。纠正肠道屏障缺陷可能对哮喘有潜在的积极预后影响。曲线下面积为0.76。它显示出等于 80% 的灵敏度和等于 71.4% 的特异性。其阴性预测值等于 83.3%。肠道屏障功能障碍有助于过敏性哮喘的发病机制。血清 zonulin 水平反映了肠道通透性的增加。Zonulin 作为哮喘严重程度的预后因素。纠正肠道屏障缺陷可能对哮喘有潜在的积极预后影响。