Stemness is now an accepted cause of treatment failure and relapse in cancer patients. Laryngeal squamous cell carcinoma patients face a high recurrence and metastatic disease. Research efforts have focused in recent years on discovering biomarkers of poor prognosis in laryngeal cancer patients. SALL4 is an embryonic stem cell factor which has been reported to be highly expressed; and to play a role in oncogenesis and progression in several malignant tumours. As of yet, the expression of this protein has not been assessed in laryngeal cancer. This study provides evidence of positive expression of this protein in laryngeal cancer cells, with positive correlation in the same tumour cells with a second stemness agent, CD 44. Furthermore, it discusses the shared pathways between the two proteins in EMT, Wnt pathway and stemness phenomenon; and proposes further studies to elucidate the role of this protein in laryngeal squamous cell carcinoma.

干性现在是癌症患者治疗失败和复发的公认原因。喉鳞状细胞癌患者面临着高复发和转移性疾病。近年来，研究工作的重点是发现喉癌患者预后不良的生物标志物。SALL4 是一种胚胎干细胞因子，据报道高度表达；并在多种恶性肿瘤的发生和进展中发挥作用。迄今为止，尚未在喉癌中评估该蛋白的表达。本研究提供了该蛋白在喉癌细胞中阳性表达的证据，在同一肿瘤细胞中与第二种干细胞因子 CD 44 呈正相关。此外，它还讨论了两种蛋白在 EMT、Wnt 途径和干细胞中的共享途径现象;