A photo-controllable TLR8 system was developed by site-specific genetic encoding of photocaged tyrosine to ensure spatiotemporal control of receptor function. The activity of TLR8 is masked in caged forms but can be restored upon decaging by exposure to UV light, making it a suitable tool for TLR8 function and regulatory mechanism studies.

中文翻译：

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通过光笼酪氨酸的基因编码对活哺乳动物细胞中先天免疫受体 TLR8 的光激活

通过光笼酪氨酸的位点特异性遗传编码开发了一种光控TLR8系统，以确保受体功能的时空控制。TLR8 的活性以笼状形式被掩盖，但可以在暴露于紫外线下脱壳后恢复，使其成为 TLR8 功能和调节机制研究的合适工具。