Irisin Enhances Angiogenesis of Mesenchymal Stem Cells to Promote Cardiac Function in Myocardial Infarction via PI3k/Akt Activation.,International Journal of Stem Cells

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Irisin Enhances Angiogenesis of Mesenchymal Stem Cells to Promote Cardiac Function in Myocardial Infarction via PI3k/Akt Activation.
International Journal of Stem Cells ( IF 2.3 ) Pub Date : 2021-08-31 , DOI: 10.15283/ijsc21005
Fan Yang _{1,

2} , Zhi Wang ₃ , Bing Li _{1,

2} , Youfu He _{1,

2} , Fawang Du _{1,

2} , Shui Tian _{1,

2} , Yu Zhang ₄ , Yongyao Yang _{1,

2}

Affiliation

With the growing incidence of acute myocardial infarction (MI), angiogenesis is vital for cardiac function post-MI. The role of bone marrow mesenchymal stem cells (BMSCs) in angiogenesis has been previously confirmed. Irisin is considered a potential vector for angiogenesis. The objective of the present study was to investigate the potential role of irisin in the angiogenesis of BMSCs.

中文翻译：

Irisin 通过激活 PI3k/Akt 增强间充质干细胞的血管生成，从而促进心肌梗塞中的心脏功能。

随着急性心肌梗死 (MI) 发病率的增加，血管生成对心肌梗死后的心脏功能至关重要。骨髓间充质干细胞 (BMSCs) 在血管生成中的作用已被证实。鸢尾素被认为是血管生成的潜在载体。本研究的目的是研究鸢尾素在 BMSCs 血管生成中的潜在作用。

更新日期：2021-08-31

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