The interactions between the tumor microenvironment and the tumor cells confers a condition that accelerate or decelerate the development of tumor. Of these cells, mesenchymal stem cells (MSCs) have the potential to modulate the tumor cells. MSCs have been established with double functions, whereby contribute to a tumorigenic or anti-tumor setting. Clinical studies have indicated the potential of MSCs to be used as tool in treating the human cancer cells. One of the advantageous features of MSCs that make them as a well-suited tool for cancer therapy is the natural tumor-trophic migration potential. A key specification of the tumor development has been stablished to be angiogenesis. As a result, manipulation of angiogenesis has become an attractive approach for cancer therapy. This review article will seek to clarify the anti-angiogenesis strategy in modulating the MSCs to treat the tumor cells.

中文翻译：

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在肿瘤治疗中操纵间充质干细胞的前景：聚光灯下的抗血管生成特性。

肿瘤微环境与肿瘤细胞之间的相互作用赋予了加速或减速肿瘤发展的条件。在这些细胞中，间充质干细胞 (MSC) 具有调节肿瘤细胞的潜力。MSC 已被建立具有双重功能，从而有助于致瘤或抗肿瘤环境。临床研究表明，MSCs 具有用作治疗人类癌细胞的工具的潜力。使它们成为非常适合癌症治疗的工具的 MSC 的优势之一是天然的肿瘤营养迁移潜力。肿瘤发展的一个关键特征已被确定为血管生成。因此，操纵血管生成已成为一种有吸引力的癌症治疗方法。