Chronic mucocutaneous candidiasis (CMC) is one of the earliest and most frequent clinical manifestations of autosomal recessive autoimmune polyendocrine syndrome type 1 (APS-1), a monogenic inborn error of immunity caused by deleterious variants of the autoimmune regulator (AIRE) gene. APS-1 patients suffer from various autoimmune diseases, due to the defective thymic deletion of autoreactive T cells, and the development of a large range of autoantibodies (auto-Abs) against various tissue antigens, and some cytokines. The mechanisms underlying CMC remained elusive for many years, until the description in 2010 of high serum titers of neutralizing auto-Abs against IL-17A, IL-17F, and/or IL-22, which are present in almost all APS-1 patients. Excessively high mucosal concentrations of IFN-γ were recently proposed as an alternative mechanism for CMC in APS-1.

中文翻译：

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APS-1 患者的念珠菌病：低 IL-17，高 IFN-γ，或两者兼而有之？

慢性皮肤黏膜念珠菌病 (CMC) 是 1 型常染色体隐性自身免疫性多内分泌综合征 (APS-1) 最早和最常见的临床表现之一，这是一种由自身免疫调节因子 (AIRE) 基因的有害变异引起的单基因先天免疫错误。由于自身反应性 T 细胞的胸腺缺失缺陷，以及针对各种组织抗原和一些细胞因子的大量自身抗体 (auto-Abs) 的发展，APS-1 患者患有各种自身免疫性疾病。多年来，CMC 的潜在机制一直难以捉摸，直到 2010 年描述了针对 IL-17A、IL-17F 和/或 IL-22 的高血清中和自身抗体滴度，这些抗体几乎存在于所有 APS-1 患者中.