Aim. This study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by the homeostasis model assessment of β cell function (HOMA-β) value and its risk factors in chronic hepatitis B (CHB) patients. Method. This cross-sectional study recruited 110 CHB patients (CHB group) and 110 patients without hepatitis B virus (non-HBV group); the groups were matched according to sex, age, and body mass index under the same glucose metabolism status. The risk factors, characteristics, and differences in glucose metabolism and HOMA-β values between the two groups were analyzed. Results. The abnormal glucose metabolism rate was higher in CHB patients with liver cirrhosis (LC) or hepatitis B envelope antigen (HBeAg) (−) status. In addition, under the same glucose metabolism status, the fasting plasma glucose (FPG) levels and 2-hour postprandial plasma glucose (2h-PG) levels in the CHB group were higher, while the HOMA-β values were significantly lower and the homeostasis model assessment of insulin resistance (HOMA-IR) value was not higher than that in the non-HBV group (all ). Further analyses revealed that the main risk factors for abnormal glucose metabolism were HBeAg (−) status and hepatitis B envelope antibody levels. But HBV serological and virological indicators had no effects on the HOMA-β values. Conclusion. Islet β cell function in patients with CHB was compromised, which is closely associated with fasting and postprandial hyperglycemia in chronic hepatitis B patients. Further research should be done to verify the compromised islet β cell function and then to investigate the mechanisms behind the effect of hepatitis B virus infection on islet β cell function in CHB patients.

中文翻译：

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慢性乙型肝炎患者胰岛β细胞功能显着下降与高血糖密切相关

目的。本研究针对慢性乙型肝炎（CHB）患者糖代谢和胰岛β细胞功能的特点，通过稳态模型评估β细胞功能（HOMA- β）值及其危险因素进行评估。方法。这项横断面研究招募了110名CHB患者（CHB组）和110名无乙型肝炎病毒患者（非HBV组）；在相同的糖代谢状态下，根据性别、年龄和体重指数进行分组。分析两组的危险因素、特点以及糖代谢和HOMA- β值的差异。结果。肝硬化（LC）或乙型肝炎包膜抗原（HBeAg）（-）状态的CHB患者糖代谢异常率较高。此外，在相同的糖代谢状态下，CHB组的空腹血糖（FPG）水平和餐后2小时血浆葡萄糖（2h-PG）水平较高，而HOMA- β值显着较低，体内平衡状态良好。胰岛素抵抗模型评估（HOMA-IR）值不高于非HBV组（全部）。进一步分析显示，糖代谢异常的主要危险因素是HBeAg（-）状态和乙型肝炎包膜抗体水平。但HBV血清学和病毒学指标对HOMA- β值没有影响。结论。慢性乙型肝炎患者的胰岛β细胞功能受损，与慢性乙型肝炎患者的空腹和餐后高血糖密切相关。应该进行进一步的研究来验证受损的胰岛β细胞功能，然后探讨乙型肝炎病毒感染对慢性乙型肝炎患者胰岛β细胞功能影响的机制