Research question

What is the association between endometrial thickness (EMT) on HCG trigger day and outcomes related to birth weight in fresh IVF and intracytoplasmic sperm injection (ICSI) embryo transfer cycles?

Design

A retrospective cohort study of 9273 singleton live births born to women undergoing fresh IVF/ICSI cycles in a single centre between January 2014 and December 2018. Multivariable logistic regression was used to investigate the associations between EMT, low birth weight (LBW) and small for gestational age (SGA). Multivariable-adjusted linear regression models incorporating restricted cubic splines were used to investigate the dose-response relationship between EMT, birth weight and birth weight z-score, respectively. An EMT of 8 mm was set as a reference value.

Results

Compared with women with an EMT of 8.0 to < 14.0 mm the risk of delivering a SGA infant was increased with EMT < 8.0 mm (adjusted odds ratio [aOR] 1.78, 95% confidence interval [CI] 1.09 to 2.90) and decreased with EMT ≥ 14.0 mm (aOR 0.57, 95% CI 0.35 to 0.93, respectively). Birth weights of infants born to women with an EMT of 8.0 mm compared with women with EMT of 5.0, 6.0, and 7.0 mm were lower by 120 g (95% CI –175 g to –66 g), 80 g (95% CI –116 g to –44 g), and 40 g (95% CI –58 g to –22 g) respectively; infant birth weight z-scores were also decreased by 0.19 (95% CI –0.27 to –0.10), 0.12 (95% CI –0.18 to –0.07) and 0.06 (95% CI –0.09 to –0.03), respectively.

Conclusions

A thinner endometrium was associated with lower birth weight and birth weight z-score, and higher risk of SGA. Women with a thin endometrium warrant special attention during pregnancy.

中文翻译：

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新鲜 IVF/ICSI 胚胎移植中子宫内膜厚度与出生体重的关系：一项对 9273 名单胎分娩的回顾性队列研究

研究问题

HCG 触发日的子宫内膜厚度 (EMT) 与新鲜 IVF 和胞浆内单精子注射 (ICSI) 胚胎移植周期中与出生体重相关的结果之间有什么关联？

设计

一项回顾性队列研究，对 2014 年 1 月至 2018 年 12 月在一个中心接受新鲜 IVF/ICSI 周期的女性所生的 9273 名单胎活产儿进行了研究。多变量逻辑回归用于研究 EMT、低出生体重 (LBW) 和小儿胎龄（SGA）。使用包含受限三次样条的多变量调整线性回归模型分别研究 EMT、出生体重和出生体重 z 评分之间的剂量反应关系。将 8 mm 的 EMT 设置为参考值。

结果

与 EMT 为 8.0 至 < 14.0 mm 的女性相比，SGA 婴儿的分娩风险在 EMT < 8.0 mm 时增加（调整优势比 [aOR] 1.78，95% 置信区间 [CI] 1.09 至 2.90）并随着 EMT 降低≥ 14.0 mm（aOR 0.57，95% CI 0.35 至 0.93，分别）。与 EMT 为 5.0、6.0 和 7.0 mm 的女性相比，EMT 为 8.0 mm 的女性所生婴儿的出生体重分别降低了 120 g（95% CI –175 g 至 –66 g）、80 g（95% CI –116 g 至 –44 g) 和 40 g (95% CI –58 g 至 –22 g)；婴儿出生体重 z 分数也分别下降了 0.19（95% CI –0.27 至 –0.10）、0.12（95% CI –0.18 至 –0.07）和 0.06（95% CI –0.09 至 –0.03）。

结论

较薄的子宫内膜与较低的出生体重和出生体重 z 评分以及较高的 SGA 风险相关。子宫内膜薄的女性在怀孕期间需要特别注意。