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Dynamic EMT: a multi-tool for tumor progression
The EMBO Journal ( IF 11.4 ) Pub Date : 2021-08-30 , DOI: 10.15252/embj.2021108647
Simone Brabletz 1 , Harald Schuhwerk 1 , Thomas Brabletz 1 , Marc P Stemmler 1
Affiliation  

The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire mesenchymal features, and become motile. In cancer, this program is hijacked to confer essential changes in morphology and motility that fuel invasion. In addition, EMT is increasingly understood to orchestrate a large variety of complementary cancer features, such as tumor cell stemness, tumorigenicity, resistance to therapy and adaptation to changes in the microenvironment. In this review, we summarize recent findings related to these various classical and non-classical functions, and introduce EMT as a true tumorigenic multi-tool, involved in many aspects of cancer. We suggest that therapeutic targeting of the EMT process will—if acknowledging these complexities—be a possibility to concurrently interfere with tumor progression on many levels.

中文翻译:

动态 EMT:肿瘤进展的多功能工具

上皮间质转化 (EMT) 过程是胚胎形态发生的基础。经历它的细胞失去上皮特征和完整性,获得间充质特征,并变得能动。在癌症中,该程序被劫持以赋予形态和运动性的基本变化,从而促进入侵。此外,越来越多的人认为 EMT 可以协调多种互补的癌症特征,例如肿瘤细胞干性、致瘤性、对治疗的抵抗力和对微环境变化的适应。在这篇综述中,我们总结了与这些各种经典和非经典功能相关的最新发现,并介绍了 EMT 作为真正的致瘤多工具,涉及癌症的许多方面。
更新日期:2021-09-15
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