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Long-term outcome in a noninvasive rat model of birth asphyxia with neonatal seizures: Cognitive impairment, anxiety, epilepsy, and structural brain alterations
Epilepsia ( IF 5.6 ) Pub Date : 2021-08-29 , DOI: 10.1111/epi.17050
Björn Gailus 1, 2 , Hannah Naundorf 1, 2 , Lisa Welzel 1 , Marie Johne 1, 2 , Kerstin Römermann 1 , Kai Kaila 3, 4 , Wolfgang Löscher 1, 2
Affiliation  

Birth asphyxia is a major cause of hypoxic–ischemic encephalopathy (HIE) in neonates and often associated with mortality, neonatal seizures, brain damage, and later life motor, cognitive, and behavioral impairments and epilepsy. Preclinical studies on rodent models are needed to develop more effective therapies for preventing HIE and its consequences. Thus far, the most popular rodent models have used either exposure of intact animals to hypoxia-only, or a combination of hypoxia and carotid occlusion, for the induction of neonatal seizures and adverse outcomes. However, such models lack systemic hypercapnia, which is a fundamental constituent of birth asphyxia with major effects on neuronal excitability. Here, we use a recently developed noninvasive rat model of birth asphyxia with subsequent neonatal seizures to study later life adverse outcome.

中文翻译:

新生儿惊厥的无创性出生窒息大鼠模型的长期结果:认知障碍、焦虑、癫痫和脑结构改变

出生窒息是新生儿缺氧缺血性脑病 (HIE) 的主要原因,通常与死亡率、新生儿癫痫发作、脑损伤以及晚年运动、认知和行为障碍以及癫痫有关。需要对啮齿动物模型进行临床前研究,以开发更有效的治疗方法来预防 HIE 及其后果。迄今为止,最流行的啮齿动物模型要么使用完整动物仅暴露于缺氧环境,要么将缺氧和颈动脉闭塞相结合,以诱导新生儿癫痫发作和不良后果。然而,这些模型缺乏全身性高碳酸血症,这是出生窒息的基本组成部分,对神经元的兴奋性有重大影响。在这里,我们使用最近开发的无创性出生窒息大鼠模型和随后的新生儿癫痫发作来研究晚年的不良后果。
更新日期:2021-11-02
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