Skin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental changes have further worsened the skin cancer statistics. The stern topical barrier although difficult to breach is a little compromised in pathologies like skin cancer. The therapeutic management of skin cancers has moved beyond chemotherapy and surgery. The quest for a magic bullet still prevails, but topical drug delivery has emerged as a perfect modality for localized self-application with minimal systemic ingress for the management of skin cancers. Advances in topical drug delivery as evidenced by the exploration of nanocarriers and newer technologies like microneedle-assisted/mediated therapeutics have revolutionized the paradigms of topical treatment. The engineered nanovectors have not only been given the liberty to experiment with a wide-array of drug carriers with very distinguishing characteristics but also endowed them with target specificity. The biologicals like nucleic acid-based approaches or skin penetrating peptide vectors are another promising area of skin cancer therapeutics which has demonstrated potential in research studies. In this review, a panoramic view is presented on the etiology, therapeutic options, and emerging drug delivery modalities for skin cancer. Nanocarriers have presented innumerable opportunities for interventions in skin cancer therapeutics. Challenge persists for the bench to bedside translation of these highly potential upcoming therapeutic strategies.

中文翻译：

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皮肤癌疗法：纳米药物递送载体——现在和以后

皮肤癌是世界范围内广泛流行的癌症形式之一。日益工业化和伴随的环境变化进一步恶化了皮肤癌的统计数据。严格的局部屏障虽然难以突破，但在皮肤癌等病理中会受到一些影响。皮肤癌的治疗管理已经超越了化疗和手术。对灵丹妙药的追求仍然盛行，但局部给药已成为局部自我应用的完美方式，其全身性侵入最小，用于治疗皮肤癌。纳米载体和微针辅助/介导疗法等新技术的探索证明了局部给药的进步已经彻底改变了局部治疗的范式。工程化的纳米载体不仅可以自由地试验具有非常显着特征的多种药物载体，而且还赋予它们靶向特异性。基于核酸的方法或皮肤穿透肽载体等生物制品是皮肤癌治疗的另一个有前途的领域，已在研究中显示出潜力。在这篇综述中，对皮肤癌的病因、治疗选择和新兴的药物递送方式进行了全景展示。纳米载体为干预皮肤癌治疗提供了无数机会。对于这些极具潜力的即将到来的治疗策略的临床转化，挑战仍然存在。基于核酸的方法或皮肤穿透肽载体等生物制品是皮肤癌治疗的另一个有前途的领域，已在研究中显示出潜力。在这篇综述中，对皮肤癌的病因、治疗选择和新兴的药物递送方式进行了全景式展示。纳米载体为干预皮肤癌治疗提供了无数机会。对于这些极具潜力的即将到来的治疗策略的临床转化，挑战仍然存在。基于核酸的方法或皮肤穿透肽载体等生物制品是皮肤癌治疗的另一个有前途的领域，已在研究中显示出潜力。在这篇综述中，对皮肤癌的病因、治疗选择和新兴的药物递送方式进行了全景展示。纳米载体为干预皮肤癌治疗提供了无数机会。对于这些极具潜力的即将到来的治疗策略的临床转化，挑战仍然存在。