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Bioactive phenylpropanoid derivatives from the fruits of Lycium ruthenicum Murr
Bioorganic Chemistry ( IF 5.1 ) Pub Date : 2021-08-30 , DOI: 10.1016/j.bioorg.2021.105307
Sen-Sen Zhao 1 , Shuang Li 2 , Zhi-Hui Luo 1 , Zheng-Qun Zhou 1 , Ning Li 2 , Ying Wang 3 , Xin-Sheng Yao 1 , Hao Gao 4
Affiliation  

Eight new (17 and 15) and 18 known (814 and 1626) phenylpropanoid derivatives were isolated from the fruits of Lycium ruthenicum Murr. (black wolfberry). Their structures were determined by comprehensive spectroscopic analyses, chemical methods, and comparisons of spectroscopic data. Four known compounds (16, 17, 24, and 26) were firstly isolated from the genus Lycium. Interestingly, compounds 1/2 and 4/5 were isolated as two pairs of inseparable anomers owing to the tautomerism of the free hemiacetal at C-1′' in solution. The antioxidant, α-glucosidase inhibitory, and acetylcholinesterase (AChE) inhibitory activities of compounds 126 were evaluated. Some compounds possessed DPPH radical scavenging activity, and all compounds (126) exhibited different levels of oxygen radical absorbance capacity (ORAC). One compound displayed α-glucosidase inhibitory activity with potency close to that of the positive control (acarbose).



中文翻译:

来自黑枸杞果实的生物活性苯丙烷衍生物

八个新(1 - 715)和18已知的(8 - 1416 - 26)苯丙烷衍生物是从的果实中分离枸杞穆尔。(黑枸杞)。它们的结构是通过综合光谱分析、化学方法和光谱数据比较确定的。四个已知化合物(161724,和26)被首先从属植物中分离枸杞。有趣的是,化合物1 / 24 / 5由于溶液中 C-1'' 处游离半缩醛的互变异构现象,它们被分离为两对不可分离的异头异构体。抗氧化剂,α葡萄糖苷酶抑制,以及化合物的乙酰胆碱酯酶抑制活性1 - 26进行了评价。具有DPPH自由基清除活性的一些化合物,并且所有化合物(1 - 26)表现出不同水平的氧自由基吸收能力(ORAC)。一种化合物显示出α-葡萄糖苷酶抑制活性,其效力接近阳性对照(阿卡波糖)。

更新日期:2021-09-02
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