Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression, development of poor prognostics, and even ascendence of the cancer-associated mortality. Early experimental investigations have proposed the theoretical potential that efficient repression of this signaling might provide promising therapeutic choices in managing various types of cancers. Up to date, many therapies targeting Wnt/β-catenin signaling in cancers have been developed, which is assumed to endow clinicians with new opportunities of developing more satisfactory and precise remedies for cancer patients with aberrant Wnt/β-catenin signaling. However, current facts indicate that the clinical translations of Wnt/β-catenin signaling-dependent targeted therapies have faced un-neglectable crises and challenges. Therefore, in this study, we systematically reviewed the most updated knowledge of Wnt/β-catenin signaling in cancers and relatively targeted therapies to generate a clearer and more accurate awareness of both the developmental stage and underlying limitations of Wnt/β-catenin-targeted therapies in cancers. Insights of this study will help readers better understand the roles of Wnt/β-catenin signaling in cancers and provide insights to acknowledge the current opportunities and challenges of targeting this signaling in cancers.

Wnt/β-连环蛋白信号传导广泛涉及人类癌症和动物实验癌症模型。Wnt/β-连环蛋白信号的异常激活与患病率的增加、恶性进展的进展、不良预后的发展，甚至癌症相关死亡率的上升密切相关。早期的实验研究提出了理论上的潜力，即有效抑制这种信号可能为治疗各种类型的癌症提供有希望的治疗选择。迄今为止，许多针对癌症中Wnt/β-catenin信号传导的疗法已经被开发出来，这被认为为临床医生提供了新的机会，为Wnt/β-catenin信号传导异常的癌症患者开发更令人满意和更精确的治疗方法。然而，目前的事实表明，Wnt/β-catenin信号依赖性靶向治疗的临床转化面临着不可忽视的危机和挑战。因此，在本研究中，我们系统回顾了癌症中Wnt/β-catenin信号传导的最新知识和相对靶向治疗，以对Wnt/β-catenin靶向治疗的发展阶段和潜在局限性有更清晰、更准确的认识。癌症疗法。这项研究的见解将帮助读者更好地了解 Wnt/β-catenin 信号在癌症中的作用，并提供见解以认识当前针对癌症中该信号的机遇和挑战。