A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.

中文翻译：

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Murrayaquinone-A 衍生物的合成和潜在抗癌特性的研究

合成了一系列新型 murrayaquinone a 衍生物，并在健康结肠癌细胞系 (CCD-18Co)、原发性 (Caco-2) 和转移性 (DLD-1) 结肠癌细胞系上评估了它们的抗癌活性。结果表明，即使在微摩尔水平，murrayaquinone 分子的细胞毒性也非常高。还进行了这些分子的DNA结合、细胞周期停滞和代谢活性研究，结果表明这些分子诱导细胞凋亡。总之，这些数据支持对murrayaquinone 衍生物的进一步研究，以选择癌症治疗的候选者。