The ubiquitous presence of legacy and emerging persistent organic pollutants (POPs) in the environmental matrices poses a potential hazard to the humans and creating public health concerns. The present study aimed to evaluate dioxins, dioxin-like polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and chlorinated paraffins (CPs) concentrations in serum of women (postpartum, pregnant and non-pregnant) from Northern Norway to better understand their exposure and contamination status as well as temporal trends across 2007–2009 (MISA 1) to 2019 (MISA 2). Sixty-two blood samples from the MISA 1 cohort and 38 samples from MISA 2 were randomly selected in this study (n = 100). Ninety samples from postpartum (MISA 1) and pregnant women (MISA 2) were randomly combined into 9 pools, with 9–11 individual samples contributing to each pool keeping the groups of pregnant and postpartum women. Remaining 10 samples from non-pregnant women (MISA 2) were allocated into separate group. Geometric mean, minimum and maximum were used to describe the serum concentrations of pooled POPs in MISA cohort. Mann-Whitney U test and independent sample t-test were applied for trend analysis of blood levels of POPs between MISA 1 and MISA 2. We found the serum concentrations of selected POPs in this study to be at lower range. Serum concentrations of dibenzo-p-dioxins (PCDDs) (p = 0.010), polychlorinated dibenzofurans (PCDFs) (p = 0.002), dioxins-like PCBs (p = 0.001), hexachlorobenzene (HCB) (p < 0.001) and p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) (p = 0.002) were decreased between the studied time. In contrast, the serum concentrations of medium chain chlorinated paraffins showed an increasing trend between 2007 and 2009 and 2019 (p = 0.019). Our findings report a particular concern of emerging contaminant medium chain chlorinated paraffin exposure to humans. Future observational studies with repeated measurements of chlorinated paraffins in general populations worldwide and large sample size are warranted.

环境基质中遗留和新出现的持久性有机污染物 (POP) 无处不在，对人类构成潜在危害，并引发公众健康问题。本研究旨在评估挪威北部妇女（产后、怀孕和未怀孕）血清中二恶英、类二恶英多氯联苯 (PCB)、有机氯农药 (OCP) 和氯化石蜡 (CP) 的浓度，以更好地了解她们的暴露情况和污染状况以及 2007-2009 (MISA 1) 到 2019 (MISA 2) 的时间趋势。在本研究中随机选择了来自 MISA 1 队列的 62 个血液样本和来自 MISA 2 的 38 个样本 (n = 100)。来自产后 (MISA 1) 和孕妇 (MISA 2) 的 90 个样本被随机组合成 9 个池，每个池中有 9-11 个单独的样本，保留孕妇和产后妇女组。来自非孕妇 (MISA 2) 的剩余 10 个样本被分配到单独的组中。几何平均值、最小值和最大值用于描述 MISA 队列中混合持久性有机污染物的血清浓度。曼-惠特尼U检验和独立样本t检验用于MISA 1和MISA 2之间POPs血液水平的趋势分析。我们发现本研究中所选POPs的血清浓度处于较低范围。二苯并二恶英 (PCDD) ( p  = 0.010)、多氯二苯并呋喃 (PCDF) ( p  = 0.002)、类二恶英多氯联苯 ( p  = 0.001)、六氯苯 (HCB) ( p  < 0.001) 和 p, p'-dichlorodiphenyldichloroethylene (p,p'-DDE) ( p  = 0.002) 在研究时间之间减少。相比之下，中链氯化石蜡的血清浓度在 2007 年和 2009 年以及 2019 年之间呈上升趋势（p = 0.019）。我们的研究结果报告了人类接触新出现的污染物中链氯化石蜡的特别关注。未来有必要对全球普通人群中的氯化石蜡进行重复测量和大样本量的观察性研究。