Abstract

The obtaining of microcarriers for the cell culture and delivery is an urgent task of tissue engineering and regenerative medicine. The novel method of surface modification of alginate microcarriers in the form of microspheres with a diameter of 200–300 μm was developed. The described method consists in covalent crosslinking between collagen and surface of alginate microcarriers. It was shown that the method makes it possible to completely modify the surface of the alginate microcarrier, which can be used to improve the biological properties of the microcarrier. Such microcarriers with improved biological properties can be considered as effective systems for cell delivery and culture.

中文翻译：

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藻酸盐微载体的表面改性以改善其生物学性能

摘要

获得用于细胞培养和递送的微载体是组织工程和再生医学的一项紧迫任务。开发了一种对直径为 200-300 μm 的微球形式的海藻酸盐微载体进行表面改性的新方法。所描述的方法在于胶原蛋白和藻酸盐微载体表面之间的共价交联。结果表明，该方法可以完全修饰海藻酸盐微载体的表面，可用于改善微载体的生物学特性。这种具有改进的生物学特性的微载体可以被认为是细胞递送和培养的有效系统。