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Acute-phase electroencephalography for an infantile atypical teratoid/rhabdoid tumor
Clinical Neurology and Neurosurgery ( IF 1.9 ) Pub Date : 2021-08-28 , DOI: 10.1016/j.clineuro.2021.106922
Yuko Ichimiya 1 , Soichi Mizuguchi 1 , Yoshitomo Motomura 1 , Yuhki Koga 1 , Noriyuki Kaku 1 , Nobuhiro Hata 2 , Koji Yoshimoto 3 , Ayumi Sakata 4 , Satoshi O Suzuki 5 , Toru Iwaki 5 , Yasunari Sakai 1 , Shouichi Ohga 1
Affiliation  

Background

Primary brain tumor is a leading cause of death in cancer-bearing children. Acutely progressive patterns of electroencephalography (EEG) remain to be investigated for children with rapidly growing brain tumors.

Case report

A 14-month-old boy was transferred to our department for prolonged seizures and unrecovered consciousness on his fifth day of illness. The EEG recording on admission showed highly disorganized background activity with high-voltage rhythmic delta waves. Serial EEG monitoring revealed a rapid transition of the background activity to the suppression-burst pattern, and then to generalized suppression of cortical activity within a few hours after admission. Magnetic resonance imaging detected a midline tumor at the pineal gland extending to the midbrain and pons. The tumor was pathologically confirmed as atypical teratoid/rhabdoid tumor (AT/RT) with absent expression of SMARCB1. He died of tumor progression on the 20th day after admission.

Conclusion

AT/RT is an additional category of brain tumors that cause the clinically and electro-physiologically critical condition in a few days after the onset.



中文翻译:

婴儿非典型畸胎样/横纹肌样肿瘤的急性期脑电图

背景

原发性脑肿瘤是导致癌症儿童死亡的主要原因。脑电图 (EEG) 的急性进展模式仍有待研究用于脑肿瘤快速生长的儿童。

案例报告

一名 14 个月大的男孩在患病第五天因长期癫痫发作和意识未恢复而被转移到我们科室。入院时的脑电图记录显示背景活动高度杂乱无章,伴有高压节律性三角波。连续脑电图监测显示背景活动快速转变为抑制爆发模式,然后在入院后几小时内全面抑制皮质活动。磁共振成像检测到松果体中线肿瘤延伸到中脑和脑桥。该肿瘤经病理学证实为非典型畸胎样/横纹肌样肿瘤(AT/RT),缺乏SMARCB1表达。他在入院后第 20 天死于肿瘤进展。

结论

AT/RT 是另一种脑肿瘤,在发病后的几天内会导致临床和电生理上的危急情况。

更新日期:2021-09-10
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