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Clavulanate combinations with mecillinam, cefixime or cefpodoxime against ESBL-producing Enterobacterales frequently associated with blaOXA-1 in a paediatric population with febrile urinary tract infections
Journal of Antimicrobial Chemotherapy ( IF 5.2 ) Pub Date : 2021-08-28 , DOI: 10.1093/jac/dkab289
André Birgy 1, 2 , Fouad Madhi 3, 4, 5 , Camille Jung 3, 6 , Corinne Levy 4, 6, 7 , Aurélie Cointe 1, 2 , Philippe Bidet 1, 2 , Claire Amaris Hobson 1 , Stéphane Bechet 7 , Elsa Sobral 7 , Hoang Vuthien 8 , Agnès Ferroni 9 , Saïd Aberrane 10 , Gaëlle Cuzon 11, 12, 13, 14 , Laetitia Beraud 15 , Vincent Gajdos 16, 17 , Elise Launay 18 , Didier Pinquier 19 , Hervé Haas 20 , Marie Desmarest 21 , Marie-Aliette Dommergues 4, 22 , Robert Cohen 4, 5, 6, 7, 23 , Stéphane Bonacorsi 1, 2
Affiliation  

Oral treatment of febrile urinary tract infections (FUTIs) can be impaired by MDR Enterobacterales often combining ESBL and inhibitor-resistant genes. We studied the impact of β-lactamases and Enterobacterales’ genotypes on the cefixime, cefpodoxime and mecillinam ± amoxicillin/clavulanate MICs.

中文翻译:

克拉维酸与美西林、头孢克肟或头孢泊肟联合用于治疗发热性尿路感染儿科人群中经常与 blaOXA-1 相关的产 ESBL 肠杆菌

MDR 肠杆菌通常结合 ESBL 和抑制剂抗性基因,可能会损害发热性尿路感染 (FUTI) 的口服治疗。我们研究了 β-内酰胺酶和肠杆菌属的基因型对头孢克肟、头孢泊肟和美西林 ± 阿莫西林/克拉维酸盐 MIC 的影响。
更新日期:2021-08-29
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