ABSTRACT

Background and Objective

Metabolic syndrome (MS) and its components are associated with greater cardiovascular risk. A number of studies found a positive association between MS and vascular damage, but few observational studies evaluated the predictive role of MS on arterial stiffening (AS). Therefore, the aim of this study was to estimate the ability of MS and its components to predict the risk of AS in an 8-year follow-up of a sample of adult men (Olivetti Heart Study).

Methods

The analysis included 778 men without AS (pulse pressure >60 mmHg) at baseline. A positive diagnosis of MS was made by recognized criteria, if at least three components were present.

Results

At the end of the follow-up period, there was an incidence of 11% in AS. The percentage of participants that developed AS was greater in the MS group than those without MS, also after adjustment for main confounders (odds ratio: 2.5, 95% confidence interval: 1.3–4.9). The risk of AS also increased with increase in the numbers of MS elements (p for trend <.01). In addition, the analysis of the predictive role of the single MS component showed that high blood pressure (HBP) was the strongest predictor.

Conclusions

The results of this prospective study indicate a predictive role of MS on AS, independently of main confounders. In addition, HBP seems the strongest predictor of AS among MS components.

中文翻译：

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代谢综合征及其成分可预测成年男性样本中动脉硬化的发展

摘要

背景与目的

代谢综合征 (MS) 及其成分与更大的心血管风险相关。许多研究发现 MS 与血管损伤之间存在正相关关系，但很少有观察性研究评估 MS 对动脉硬化 (AS) 的预测作用。因此，本研究的目的是在对成年男性样本的 8 年随访中评估 MS 及其成分预测 AS 风险的能力（Olivetti 心脏研究）。

方法

该分析包括 778 名基线时无 AS（脉压 >60 mmHg）的男性。如果存在至少三个成分，则根据公认的标准做出 MS 的阳性诊断。

结果

在随访期结束时，AS 的发生率为 11%。在调整主要混杂因素后，MS 组中发生 AS 的参与者的百分比高于没有 MS 的参与者（优势比：2.5，95% 置信区间：1.3-4.9）。AS 的风险也随着 MS 元素数量的增加而增加（趋势p <.01）。此外，对单一 MS 成分的预测作用的分析表明，高血压 (HBP) 是最强的预测因子。

结论

这项前瞻性研究的结果表明 MS 对 AS 具有预测作用，与主要混杂因素无关。此外，HBP 似乎是 MS 成分中最强的 AS 预测因子。