As global vaccine production capacity is limited, every optimization strategy must be explored to rapidly increase the number of people vaccinated. The objective of this study is to determine which medical devices allow the extraction of the maximum number of doses from different vaccine vials (Pfizer-BioNTech, AstraZeneca, Moderna and Johnson & Johnson vaccines) by analyzing all the factors involved in the preparation of the injected doses. By measuring the dead-volume of 32 syringe-needle combinations, we show that fixed-needle syringe with a dead-volume of less than 5 µL can extract up to 7 doses from Pfizer vials, 13 doses from AstraZeneca vials, 12 doses from Moderna vials and 6 doses from Johnson & Johnson vials. We found that the syringe accuracy is important, and can compromise the chances of extracting additional doses when withdrawing too large a volume. For Pfizer vaccine, particular attention must be paid to the choice of dilution syringe, which may compromise the extraction of the 7th dose. The withdrawal of extra doses from vaccine vials was not operator-dependent. In this unprecedented health context, the medical device considerations presented here could help to optimize every COVID-19 vaccine vial.

由于全球疫苗生产能力有限，必须探索各种优化策略以快速增加接种人数。本研究的目的是通过分析注射疫苗制备过程中涉及的所有因素，确定哪些医疗设备允许从不同疫苗瓶（辉瑞-BioNTech、阿斯利康、Moderna 和强生疫苗）中提取最大剂量剂量。通过测量 32 种注射器-针头组合的死体积，我们表明死体积小于 5 µL 的固定针注射器最多可以从辉瑞小瓶中提取 7 剂，从阿斯利康小瓶中提取 13 剂，从 Moderna 中提取 12 剂小瓶和 6 剂强生小瓶。我们发现注射器的准确性很重要，并且在提取体积过大时可能会影响提取额外剂量的机会。对于辉瑞疫苗，必须特别注意稀释注射器的选择，这可能会影响第 7 剂的提取。从疫苗瓶中取出额外剂量不依赖于操作员。在这种前所未有的健康背景下，此处介绍的医疗设备注意事项可能有助于优化每个 COVID-19 疫苗瓶。