Prostate cancer (PCa) is the most common visceral malignancy and the second leading cause of cancer deaths in US men. The two most common genetic alterations in PCa are expression of the TMPRSS2/ERG (TE) fusion gene and loss of the PTEN tumor suppressor. These genetic alterations act cooperatively to transform prostatic epithelium but the exact mechanisms involved are unclear.

中文翻译：

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MEX3D 是前列腺癌的致癌驱动因子

前列腺癌 (PCa) 是最常见的内脏恶性肿瘤，也是美国男性癌症死亡的第二大原因。PCa 中两种最常见的遗传改变是 TMPRSS2/ERG (TE) 融合基因的表达和 PTEN 肿瘤抑制基因的缺失。这些遗传改变协同作用以转化前列腺上皮，但所涉及的确切机制尚不清楚。