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Biocompatible Eu doped mesoporous calcium silicate nanospheres for pH-responsive drug release
Inorganic Chemistry Communications ( IF 3.8 ) Pub Date : 2021-08-28 , DOI: 10.1016/j.inoche.2021.108872
Duo Wang 1, 2 , Shixing Han 1 , Bing-Bing Lu 1
Affiliation  

Calcium silicate is a kind of inorganic biomaterial containing Si, Ca, O elements, they have been widely investigated and applied in a variety of medical applications in the past four decades. Herein, Europium (Eu) doped mesoporous calcium silicate nanoparticles (Eu-MCS) with sizes ranging from 60 nm to 110 nm were prepared via a simple hydrothermal synthesis method. The morphology, structure, texture and optical property were characterized by SEM, TEM, XRD, N2 adsorption/desorption and PL spectra, respectively. The prepared material emits strong red luminescence at 613 nm upon UV irradiation and is cytocompatible at a wide range of concentrations, exibiting promising application in bioimaging. The Eu-MCS has a high loading capacity of 356.67 μg/mg for the anticancer drug DOX, and the drug loaded material DOX@Eu-MCS showed pH-controlled drug release behaviour. Moreover, both of the biocompatibility tests on normal human cells HEK293 and human colon cancer cells HT29 indicate a low cytotoxicity of Eu-MCS. The cell cytotoxity assays of the DOX loaded nanomaterial (DOX@Eu-MCS) on Hela cancer cells prove a high cancer cell mortality. Therefore, the as-prepared red emissive nanocarrier Eu-MCS has great potential to be used as an integrated platform for cancer diagnosis and therapy.



中文翻译:

用于 pH 响应药物释放的生物相容性 Eu 掺杂介孔硅酸钙纳米球

硅酸钙是一种含有Si、Ca、O元素的无机生物材料,在过去的40年里,它们被广泛研究并应用于各种医学领域。在此,通过简单的水热合成方法制备了尺寸范围为 60 nm 至 110 nm 的铕 (Eu) 掺杂介孔硅酸钙纳米粒子 (Eu-MCS)。通过SEM、TEM、XRD、N 2 对其形貌、结构、织构和光学性能进行表征分别为吸附/解吸和 PL 光谱。所制备的材料在紫外线照射下在 613 nm 处发出强烈的红色发光,并且在很宽的浓度范围内具有细胞相容性,在生物成像中具有广阔的应用前景。Eu-MCS 对抗癌药物 DOX 具有 356.67 μg/mg 的高负载能力,并且载药材料 DOX@Eu-MCS 显示出 pH 控制的药物释放行为。此外,对正常人细胞 HEK293 和人结肠癌细胞 HT29 的生物相容性测试均表明 Eu-MCS 的细胞毒性较低。加载 DOX 的纳米材料 (DOX@Eu-MCS) 对 Hela 癌细胞的细胞毒性测定证明癌细胞死亡率很高。因此,所制备的红色发光纳米载体 Eu-MCS 具有用作癌症诊断和治疗的集成平台的巨大潜力。

更新日期:2021-09-01
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