In this work, we report the syntheses and characterizations of two titanium-based metal–organic frameworks (Ti-MOFs), MIL-125 and MIL-125-NH₂ as potential drug carriers for chloroquine (CQ). Both materials exhibited high loading capability for CQ owing to their large surface area. The sustainable CQ release could reach ca. 70% after 13 days in phosphate buffer solution. The experimental results suggested that Ti-MOFs could be a valuable CQ carriers to realize the slow release.

中文翻译：

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钛基金属有机骨架作为潜在的氯喹药物载体

在这项工作中，我们报告了两种钛基金属-有机骨架 (Ti-MOF)，MIL-125 和 MIL-125-NH ₂作为氯喹 (CQ) 的潜在药物载体的合成和表征。由于它们的大表面积，这两种材料都表现出对 CQ 的高负载能力。可持续的 CQ 发布可能会达到大约。在磷酸盐缓冲溶液中 13 天后浓度为 70%。实验结果表明，Ti-MOFs 可能是实现缓释的有价值的 CQ 载体。