当前位置: X-MOL 学术BBA Gene Regul. Mech. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
R-loop and its functions at the regulatory interfaces between transcription and (epi)genome
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms ( IF 4.7 ) Pub Date : 2021-08-28 , DOI: 10.1016/j.bbagrm.2021.194750
Arum Kim 1 , Gang Greg Wang 2
Affiliation  

R-loop represents a prevalent and specialized chromatin structure critically involved in a wide range of biological processes. In particular, co-transcriptional R-loops, produced often due to RNA polymerase pausing or RNA biogenesis malfunction, can initiate molecular events to context-dependently regulate local gene transcription and crosstalk with chromatin modifications. Cellular “readers” of R-loops are identified, exerting crucial impacts on R-loop homeostasis and gene regulation. Mounting evidence also supports R-loop deregulation as a frequent, sometimes initiating, event during the development of human pathologies, notably cancer and neurological disorder. The purpose of this review is to cover recent advances in understanding the fundamentals of R-loop biology, which have started to unveil complex interplays of R-loops with factors involved in various biological processes such as transcription, RNA processing and epitranscriptomic modification (such as N6-methyladenosine), DNA damage sensing and repair, and epigenetic regulation.



中文翻译:

R环及其在转录和(表观)基因组之间的调节界面上的功能

R-loop 代表了一种普遍的和特殊的染色质结构,它与广泛的生物过程密切相关。特别是,通常由于 RNA 聚合酶暂停或 RNA 生物发生故障而产生的共转录 R 环可以启动分子事件,以上下文依赖性调节局部基因转录和与染色质修饰的串扰。识别出 R-loop 的细胞“阅读器”,对 R-loop 产生至关重要的影响稳态和基因调控。越来越多的证据也支持 R 环失调是人类病理发展过程中的一种常见事件,有时是起始事件,特别是癌症和神经系统疾病。这篇综述的目的是涵盖理解 R 环生物学基础的最新进展,这些进展已经开始揭示 R 环与参与各种生物过程的因素之间的复杂相互作用,如转录、 RNA 加工和表观转录组修饰(如N6-甲基腺苷)、DNA 损伤感知和修复以及表观遗传调控。

更新日期:2021-09-07
down
wechat
bug